| Il viaggio del dollaro d'argento | 2021 | Gabriele Panini, Alessandro Gottardo | Story | 30 | Italy | 52 |
| Zio Paperone, Battista e i segreti del deposito | 2021 | Alessandro Sisti, Giuseppe Facciotto | Story | 72 | Italy | 32 |
| Paperin Pigafetta Oltre i confini del mondo | 2021 | Pietro Zemelo, Paolo Mottura | Story | 92 | Italy | 27 |
| La Banda Bassotti e il furto quasi perfetto | 2021 | Silvia Ziche | Story | 60 | Italy | 20 |
| Calisota Summer Cup | 2021 | Marco Nucci, Stefano Intini | Story | 122 | Italy | 17 |
| Zio Paperone e il profumo del tempo | 2021 | Fabio Michelini, Andrea Ferraris | Story | 22 | Italy | 16 |
| Eager Beagles | 2021 | Tormod Løkling, Arild Midthun | Story | 16 | Denmark | 14 |
| Untitled cover | 2021 | Arild Midthun | Cover | 1 | Denmark | 13 |
| I Bassotti, Zio Paperone in droni, cloni &... bidoni | 2021 | Alessio Coppola | Story | 28 | Italy | 11 |
| Zio Paperone e la bolla dei papcoin | 2021 | Fausto Vitaliano, Giampaolo Soldati | Story | 30 | Italy | 9 |
| 70 Jahre Panzerknacker | 2021 | Andrea Freccero | Cover | 1 | Denmark | 7 |
| Untitled cover | 2021 | Paolo Mottura | Cover | 1 | Italy | 7 |
| Zio Paperone e le case mobili | 2021 | Fabio Michelini, Marco Palazzi | Story | 24 | Italy | 6 |
| Newton Pitagorico in... sono solo pensieri | 2021 | Marco Nucci, Simona Capovilla | Story | 30 | Italy | 5 |
| Untitled cover | 2021 | Andrea Freccero | Cover | 1 | Italy | 5 |
| Teveel kerstmannen | 2021 | Evert Geradts, Daan Jippes | Story | 12 | Holland | 4 |
| Neve artistica | 2021 | Angelo Palmas, Giulia Lomurno | Story | 1 | Italy | 4 |
| Slapend rijk | 2021 | Ralph du Mosch, Daan Jippes | Story | 8 | Holland | 3 |
| Untitled illustration | 2021 | Silvia Ziche | Illustration | | Italy | 3 |
| ...a Paperopoli | 2021 | Silvia Ziche | Story | 1 | Italy | 2 |
| Op bezoek bij... De Zware Jongens | 2021 | Lotte Roep, Jan-Roman Pikula | Illustration | 1 | Holland | 1 |
| Zio Paperone e il catasto catastrofico | 2021 | Alessandro Sisti, Roberto Marini | Story | 18 | Italy | 1 |
| Untitled illustration | 2021 | Giuseppe Facciotto | Illustration | | Italy | 1 |
| Untitled illustration | 2021 | Giuseppe Facciotto | Illustration | | Italy | 1 |
| Arild Midthun - den norske troldmand fra Bergen | 2021 | Svend Skytte | Article | 2 | Non-Disney and/or non-comics | 1 |
| Think pink! | 2021 | Barbara Garufi, Silvia Ziche | Article | 5 | Non-Disney and/or non-comics | 1 |
| Untitled cover | 2021 | Paolo Mottura | Cover | 2 | Finland | 1 |
| Untitled cover | 2021 | Paolo Mottura | Cover | 1 | Finland | 1 |