| Zio Paperone e la ventiquattrore di Paperopoli | 2021 | Alessandro Sisti, Mario Ferracina | Story | 76 | Italy | 49 |
| Qui Quo Qua in: Viaggio nel micromondo | 2021 | Sergio Cabella, Giampaolo Soldati | Story | 69 | Italy | 37 |
| Gastone e la solitudine del quadrifoglio | 2021 | Marco Nucci, Stefano Zanchi | Story | 52 | Italy | 26 |
| The Snooze Button | 2021 | Kari Korhonen | Story | 11 | Denmark | 14 |
| Archimede e la normale vacanza geniale | 2021 | Vito Stabile, Valerio Held | Story | 24 | Italy | 14 |
| The Science Project | 2021 | Sune Troelstrup, Marco Rota | Story | 10 | Denmark | 12 |
| A Visit to Grubkcud | 2021 | Jaakko Seppälä, Cèsar Ferioli Pelaez | Story | 10 | Denmark | 11 |
| Space Raiders | 2021 | Sune Troelstrup, Carmen Pérez | Story | 10 | Denmark | 11 |
| The Wounded Squirrel | 2021 | Maya Åstrup, Carmen Pérez | Story | 6 | Denmark | 11 |
| Freefall Vehicle | 2021 | Andreas Pihl, Massimo Fecchi | Story | 26 | Denmark | 11 |
| Moonlight Festival | 2021 | Gorm Transgaard, Carmen Pérez | Story | 10 | Denmark | 11 |
| Donald's Little Helper | 2021 | Carol McGreal, Maria José Sánchez Núñez | Story | 6 | Denmark | 10 |
| Weekje zomer 6 | 2021 | Jan Vijver, José Antonio González | Story | <1 | Holland | 10 |
| Le orripilanti bomboniere di Pico de Paperis | 2021 | Francesco Vacca, Mattia Surroz | Story | 12 | Italy | 10 |
| Stain-proof suit | 2021 | Francesco Artibani, Arild Midthun | Story | 6 | Disney Publishing Worldwide (global) | 10 |
| The Vanishing Island | 2021 | Kari Korhonen | Story | 6 | Denmark | 9 |
| The Amazing Colossal Big Helper | 2021 | Carol McGreal, Sebastián Puñales | Story | 4 | Denmark | 9 |
| The Traps | 2021 | Gaute Moe, Carmen Pérez | Story | 3 | Denmark | 9 |
| Obviously Obsolete | 2021 | Carol McGreal, Diego Bernardo | Story | 3 | Denmark | 9 |
| Artistic Flair | 2021 | Jaakko Seppälä, Fernando Güell | Story | 3 | Denmark | 9 |
| Untitled cover | 2021 | Francisco Rodriguez Peinado | Cover | 1 | Denmark | 8 |
| Untitled cover | 2021 | Kari Korhonen | Cover | 1 | Denmark | 8 |
| in: het parkmonster | 2021 | Hugo Sauer, Carlos Mota | Story | 8 | Holland | 8 |
| Cassandra | 2021 | Oscar ten Houten, Sebastián Puñales | Story | 8 | Holland | 8 |
| Bamboe | 2021 | Evert Geradts, Daan Jippes | Story | 10 | Holland | 8 |
| Untitled cover | 2021 | Maarten Gerritsen | Cover | 1 | Holland | 8 |
| Zio Paperone e la Gazzella del Nord | 2021 | Vito Stabile, Marco Rota | Story | 26 | Italy | 8 |
| The Inventor's Challenge | 2021 | Alessandro Ferrari, Wanda Gattino | Story | 6 | Disney Publishing Worldwide (global) | 8 |
| There's No Dimension Like Home | 2021 | Sune Troelstrup, Maria José Sánchez Núñez | Story | 4 | Denmark | 7 |
| The Age of Code | 2021 | Jaakko Seppälä, Cynthia Campanario Pineda | Story | 1 | Denmark | 7 |
| De kookrobot | 2021 | Alex van Koten, Jordi Alfonso | Story | 4 | Holland | 7 |
| Brievenbus | 2021 | Herman Roozen, Carmen Pérez | Story | 3 | Holland | 7 |
| De schat van Zwemvlieseiland | 2021 | Frank Jonker, Francisco Rodriguez Peinado | Story | 6 | Holland | 7 |
| W.T.T. - Hobby horse | 2021 | | Text story | 2 | Denmark | 6 |
| Ruimtegebrek | 2021 | Frank Jonker, Maria José Sánchez Núñez | Story | 4 | Holland | 6 |
| IJshoofdband | 2021 | Erik Haverkort, Carmen Pérez | Story | <1 | Holland | 6 |
| de gluiperige sluipwesp | 2021 | Robbert Damen, Tim Artz | Story | 8 | Holland | 6 |
| Teleporteur | 2021 | Jonathan van Engelenhoven, José Antonio González | Story | 4 | Holland | 6 |
| Destination: Vacation | 2021 | Silvia Martinoli, Giada Perissinotto | Story | 24 | Disney Publishing Worldwide (global) | 6 |
| W.T.T. - Crazy biker boat | 2021 | | Text story | 2 | Denmark | 5 |
| Untitled cover | 2021 | | Cover | 1 | Denmark | 5 |
| ...a Paperopoli | 2021 | Silvia Ziche | Story | 1 | Italy | 5 |
| Newton Pitagorico in... sono solo pensieri | 2021 | Marco Nucci, Simona Capovilla | Story | 30 | Italy | 5 |
| Untitled cover | 2021 | Francisco Rodriguez Peinado | Cover | 1 | Finland | 5 |
| W.T.T. - Gold, gold, gold! | 2021 | | Text story | 2 | Denmark | 4 |
| W.T.T. - Remain seated ... | 2021 | | Text story | 2 | Denmark | 4 |
| W.T.T. - Couch-excuses | 2021 | | Text story | 2 | Denmark | 4 |
| W.T.T. - Checkmate! | 2021 | | Text story | 2 | Denmark | 4 |
| Willie Paaseieren/batterijen | 2021 | Jan Kruse, Angel Rodriguez | Cover | 1 | Holland | 4 |
| Paperino e il gigantesco problema floreale | 2021 | Francesco Vacca, Ivan Bigarella | Story | 14 | Italy | 4 |
| Ray e il grande esperimento | 2021 | Roberto Gagnor, Libero Ermetti | Story | 20 | Italy | 4 |
| Vent'anni dopo | 2021 | Marco Nucci, Libero Ermetti | Story | 34 | Italy | 4 |
| Untitled illustration | 2021 | | Illustration | | Italy | 4 |
| Destination: Tomatoes | 2021 | Francesco Artibani, Francesco D'Ippolito | Story | 24 | Disney Publishing Worldwide (global) | 4 |
| Destination: Tires | 2021 | Silvia Martinoli, Lorenzo Pastrovicchio | Story | 24 | Disney Publishing Worldwide (global) | 4 |
| Destination: Leonardo | 2021 | Vito Stabile, Paolo De Lorenzi | Story | 24 | Disney Publishing Worldwide (global) | 4 |
| Destination: Telephone | 2021 | Francesco Artibani, Alessandro Pastrovicchio | Story | 24 | Disney Publishing Worldwide (global) | 4 |
| Destination: Ancient Egypt | 2021 | Silvia Martinoli, Luca Usai | Story | 24 | Disney Publishing Worldwide (global) | 4 |
| Voyage to the Bottom of the Hole | 2021 | Luciano Bottaro | Story | 1 | Miscellaneous | 3 |
| W.T.T. - Bon appetit! | 2021 | | Text story | 2 | Denmark | 3 |