| Tip & Tap e l'invasione dei droni | 2021 | Pietro Zemelo, Luca Usai | pencils, ink | Story | 32 | Italy | 29 |
| The Cauldron of Discord | 2021 | Riccardo Pesce, Luca Usai | pencils | Story | 22 | Disney Publishing Worldwide (global) | 11 |
| Topolino, Pippo e la logica illogico-provvidenziale | 2021 | Giulio D'Antona, Luca Usai | pencils, ink | Story | 36 | Italy | 7 |
| San Romolo 2021 | 2021 | Pietro Zemelo, Alessandro Perina | pencils, ink | Story | 40 | Italy | 4 |
| Christmas... Insured! | 2021 | Chantal Pericoli, Luca Usai | pencils | Story | 22 | Disney Publishing Worldwide (global) | 4 |
| The Christmas Conspiracy | 2021 | Silvia Martinoli, Luca Usai | pencils | Story | 22 | Disney Publishing Worldwide (global) | 4 |
| Destination: Ancient Egypt | 2021 | Silvia Martinoli, Luca Usai | pencils, ink | Story | 24 | Disney Publishing Worldwide (global) | 4 |
| Virtual Success! | 2021 | Augusto Macchetto, Luca Usai | pencils, ink | Story | 4 | Disney Publishing Worldwide (global) | 3 |
| L'età delle invenzioni | 2021 | Augusto Macchetto, Luca Usai | pencils, ink | Story | 30 | Italy | 2 |
| Artistic Movements! | 2021 | Simona Grandi, Luca Usai | pencils, ink | Story | 1 | Disney Publishing Worldwide (global) | 2 |
| Eye Spy | 2021 | | pencils, ink | Game or puzzle | 1 | Disney Publishing Worldwide (global) | 2 |
| Untitled illustration | 2021 | Luca Usai | pencils, ink | Illustration | | Italy | 1 |
| Untitled illustration | 2021 | Luca Usai | pencils, ink | Illustration | | Italy | 1 |
| Untitled illustration | 2021 | Luca Usai | pencils, ink | Illustration | | Italy | 1 |
| (Massimo Gramellini) | 2021 | Luca Usai | pencils, ink | Illustration | | Italy | 1 |
| Di quale segno sei? | 2021 | Santo Scarcella, Luca Usai | pencils, ink | Article | 4 | Non-Disney and/or non-comics | 1 |
| I ciondoli dello zodiaco | 2021 | Santo Scarcella, Luca Usai | pencils, ink | Article | 2 | Non-Disney and/or non-comics | 1 |
| Woodchuck Wardrobe | 2021 | | pencils, ink | Game or puzzle | 1 | Disney Publishing Worldwide (global) | 1 |
Italy