| Rusty Haller | United States | 1995–1997 | pencils | | 2 |
| Ryan G. Browne | | 2023 | pencils, ink | | 2 |
| S. La Bruna | | 1941 | plot, script | | 2 |
| Sakari Toiviainen | | 1983 | plot, script | | 2 |
| Sam Cornell | United States | 1975–1976 | plot, script | | 2 |
| Sami Toivonen | | 2001–2011 | plot, script, pencils, ink | | 2 |
| Samim Utkun | | 1955 | pencils, ink | | 2 |
| Sammeli Pieviläinen | | 2023 | plot, script, pencils, ink | | 2 |
| Sampo Holopainen | | 2023 | plot, script, pencils, ink | | 2 |
| Sampsa Kuukasjärvi | | 2007–2015 | plot, script | | 2 |
| Samuel Raisvuo | | 2023 | plot, script, pencils, ink | | 2 |
| Sanna Savolainen | | 2010–2012 | plot, script | | 2 |
| Sarah Flanagan | United States | 1995–1996 | ink | | 2 |
| Saturno | | 1941–1942 | plot, script | | 2 |
 | Scott Gimple | United States | 1998 | plot, script | | 2 |
| Scott Goodall | | 1994–1996 | script | | 2 |
| Scott Rosema | United States | 1995–1996 | pencils | | 2 |
| Seb van der Kaaden | | 2014–2024 | plot, script | | 2 |
| Sebastian Bauer | | 2008–2024 | plot, script | | 2 |
| Selma Poni | Brazil | 1982 | ink | | 2 |
| Sem Anne van Dijk | | 2023 | plot, script | | 2 |
| Sergio Lama | | 2011–2013 | plot, script | | 2 |
| Sergio Tuis | Italy | 1985 | pencils, ink | | 2 |
| Seung Beom Kim | | 2015–2016 | pencils, ink | | 2 |
| Sezai Attila | Turkey | 1935 | plot, script | | 2 |
| Shatoki Shiki | | 2026 | pencils, ink | | 2 |
| Sib Ventress | United States | 1999 | plot, script | | 2 |
| Sidney Schering | | 2012–2018 | plot, script | | 2 |
| Sigi Hepner | Germany | 1993–2003 | plot, script | | 2 |
| Siiri Riikonen | | 2023 | plot, script, pencils, ink | | 2 |
| Silver | | 1994–2014 | plot, script, pencils, ink | | 2 |
| Silvia De Ventura | | 2025 | ink | | 2 |
| Simen V. Gonsholt | | 2008–2010 | plot, script | | 2 |
| Simon Sahlberg | | 1993 | plot, script | | 2 |
| Simone D'Armini | | 2024 | pencils, ink | | 2 |
| Simone Spitolni | | 2026 | plot, script | | 2 |
| Sirio Consani | | 2024 | plot, script | | 2 |
| Sissi_XD | | 2012–2013 | plot, script | | 2 |
| Skip Epperson | | 1980–1985 | pencils, ink | | 2 |
| Slava Panarin | | 2010 | pencils, ink | | 2 |
| Sorrenti | Italy | 1975 | plot, script | | 2 |
| Stefan Pannor | | 2012–2023 | plot, script | | 2 |
| Stefan Schnell | | 2003 | plot, script | | 2 |
| Stefania Sapuppo | | 2019–2021 | plot, script | | 2 |
| Stefano Feltri | | 2026 | plot, script | | 2 |
| Stefano Gorla | | 2000–2005 | plot, script | | 2 |
| Stefano Petricca | | 1993 | plot, script | | 2 |
| Stefano Preziosi | | 2013 | plot, script | | 2 |
| Stefano Rolli | | 1999–2002 | plot, script, pencils, ink | | 2 |
| Steffi Jungmann | | 2019–2020 | plot, script, pencils, ink | | 2 |
| Stella Vegan | | 2009 | plot, script | | 2 |
| Sten Nilsson | Sweden | 1998–1999 | plot | | 2 |
 | Stephanie Gladden | United States | 1998–1999 | pencils, ink | | 2 |
| Steve Ahlquist | United States | 2006–2007 | plot, script | | 2 |
| Steve Greenberg | United States | 1990 | plot, script | | 2 |
| Steven B. Clark | | 2012–2013 | plot, script | | 2 |
| Steven Clark | | 2009 | plot, script | | 2 |
| Steven Daily | | 2006 | pencils, ink | | 2 |
| Stig Wiedemann Smith | | 1975–1979 | plot, script | | 2 |
| Stéphane Kœchlin | France | 1999 | plot, script | | 2 |