| Simon Trevor Collins | 2010 | | 0 | 1 |
| Simon the snail | 2011 | | 0 | 1 |
| Simon the sorcerer | 1981 | | 0 | 1 |
| Simone from B 840076 | 1985 | | 0 | 1 |
| Simone from Belle's Friendship Invention | 2017 | | 0 | 1 |
| Simple Simon | 1933 | | 0 | 1 |
| Simão Leve | 1983 | | 0 | 1 |
| Simão the gorilla | 1992 | | 0 | 1 |
| Sinclair the puppet | 1956 | | 0 | 1 |
| Sindaco di Topolinia | 2024 | | 0 | 1 |
| Sindoval from B 920332 | 1993 | | 0 | 1 |
| Sinead | 1999 | | 0 | 1 |
| Sinna Suokurki | 2018 | | 0 | 1 |
| Sinésio from B 770292 | 1978 | | 0 | 1 |
| Sir Brian's dog Fido | 1984 | | 0 | 1 |
| Sir Brian's dog from YW 83-12-09 | 1983 | | 0 | 1 |
| Sir Brian's guardian angel | 1987 | | 0 | 1 |
| Sir Brian's poodle | 1983 | | 0 | 1 |
| Sir Falcão | 1974 | | 0 | 1 |
| Sir Guy Standforth | 2011 | | 0 | 1 |
| Sir Maltus | 1972 | | 0 | 1 |
| Sir Naduck | 2014 | | 0 | 1 |
| Sir Tops de Tops | 2016 | | 0 | 1 |
| Sir Weakley | 1981 | | 0 | 1 |
| Sis Duckling | 1948 | | 0 | 1 |
| Sis Muskrat | 1997 | | 0 | 1 |
| Sis Owl | 1945 | | 0 | 1 |
| Sis Possum | 1946 | | 0 | 1 |
| Sis Rabbit | 2023 | | 0 | 1 |
| Sissi Rigaita | 1991 | | 0 | 1 |
| Sister Bunny | 1960 | | 0 | 1 |
| Sister Bunny's children | 1960 | | 0 | 1 |
| Sister Dove | 2008 | | 0 | 1 |
| Sixtar | 2012 | | 0 | 1 |
| Sjaak Spin from H 28337 | 2010 | | 0 | 1 |
| Sjaak Steenhommel | 1997 | | 0 | 1 |
| Skag and Bruno | 1977 | | 0 | 1 |
| Skakkr | 2019 | | 0 | 1 |
| Skinny-001/2 | 1972 | | 0 | 1 |
| Skip Ricter | 2008 | | 0 | 1 |
| Skipper Mallard | 1975 | | 0 | 1 |
| Skipper the dog | 1960 | | 0 | 1 |
| Skrattis | 2010 | | 0 | 1 |
| Skylar Vega | 2017 | | 0 | 1 |
| Sleepy from TL 3682 | 2026 | | 0 | 1 |
| Slim Jack | 2023 | | 0 | 1 |
| Slim from I TL 2781-3 | 2009 | | 0 | 1 |
| Slink | 1977 | | 0 | 1 |
| Sludge | 1983 | | 0 | 1 |
| Slugger McSock | 1961 | | 0 | 1 |
| Slurk | 1960 | | 0 | 1 |
| Sly from W SG 53-03 | 1979 | | 0 | 1 |
| Slye McDuck | 1959 | | 0 | 1 |
| Small Bulldog | 1977 | | 0 | 1 |
| Smarty Pants | 2026 | | 0 | 1 |
| Smeralda the snail | 2008 | | 0 | 1 |
| Smiley Dobbs | 2013 | | 0 | 1 |
| Smilzo | 1985 | | 0 | 1 |
| Smithson | 2013 | | 0 | 1 |
| Smitty from W SG 74-03 | 1984 | | 0 | 1 |