| Siamo serie! | 2021 | Sergio Badino, Silvia Ziche | Story | 100 | Italy | 52 |
| Zio Paperone e la ventiquattrore di Paperopoli | 2021 | Alessandro Sisti, Mario Ferracina | Story | 76 | Italy | 49 |
| Grosso guaio a Paperopoli | 2021 | Alex Bertani, Giuseppe Facciotto | Story | 84 | Italy | 47 |
| Mi chiamo Paperinik | 2021 | Marco Gervasio, Davide Cesarello | Story | 56 | Italy | 44 |
| Ducktopia | 2021 | Francesco Artibani, Francesco D'Ippolito | Story | 96 | Italy | 33 |
| Musicalisota | 2021 | Giorgio Salati, Nicolino Picone | Story | 166 | Italy | 30 |
| Paperinik e la minaccia dal passato | 2021 | Riccardo Pesce, Giuseppe Facciotto | Story | 43 | Italy | 26 |
| A Christmas Coot | 2021 | Marco Nucci, Paolo Mottura | Story | 40 | Italy | 21 |
| Going for the Gold | 2021 | Sune Troelstrup, Massimo Fecchi | Story | 30 | Denmark | 18 |
| Burning Rubber in Monte Palma | 2021 | Andreas Pihl, Andrea Ferraris | Story | 30 | Denmark | 18 |
| Meet the New Kids | 2021 | | Article | 1 | Disney Publishing Worldwide (global) | 18 |
| Calisota Summer Cup | 2021 | Marco Nucci, Stefano Intini | Story | 122 | Italy | 17 |
| A Day at the Beach | 2021 | Gorm Transgaard, Flemming Andersen | Story | 36 | Denmark | 16 |
| Penguins, Hats and 100 kg of Gold | 2021 | Pietro Zemelo, Andrea Ferraris | Story | 30 | Denmark | 14 |
| The Nightmare Mystery | 2021 | Lars Jensen, Andrea Freccero | Story | 28 | Denmark | 14 |
| The Snooze Button | 2021 | Kari Korhonen | Story | 11 | Denmark | 14 |
| The Slow Camera | 2021 | Arild Midthun | Story | 10 | Denmark | 14 |
| Archimede e la normale vacanza geniale | 2021 | Vito Stabile, Valerio Held | Story | 24 | Italy | 14 |
| Musica, Maestro! | 2021 | Giorgio Fontana, Donald Soffritti | Story | 12 | Italy | 14 |
| Heroes of the Myth | 2021 | Jaakko Seppälä, Francisco Rodriguez Peinado | Story | 10 | Denmark | 13 |
| Untitled cover | 2021 | Maarten Gerritsen | Cover | 1 | Holland | 13 |
| Paperino e l'agognato condizionatore | 2021 | Bruno Sarda, Giampaolo Soldati | Story | 16 | Italy | 13 |
| Blooming Business | 2021 | Sune Troelstrup, Cynthia Campanario Pineda | Story | 5 | Denmark | 12 |
| Decreasing Duck | 2021 | Tormod Løkling, Arild Midthun | Story | 10 | Denmark | 12 |
| Pico e gli hashtag su misura | 2021 | Alessandro Sisti, Federico Franzò | Story | 8 | Italy | 12 |
| The Skiing Ace | 2021 | Gaute Moe, Sebastián Puñales | Story | 2 | Denmark | 11 |
| Captivating Coup | 2021 | Jaakko Seppälä, Carlos Mota | Story | 10 | Denmark | 11 |
| Girls to the Rescue | 2021 | Maya Åstrup, Cynthia Campanario Pineda | Story | 8 | Denmark | 11 |
| Necessity - The Mother of Inventions | 2021 | Jaakko Seppälä, Francisco Rodriguez Peinado | Story | 10 | Denmark | 11 |
| A Visit to Grubkcud | 2021 | Jaakko Seppälä, Cèsar Ferioli Pelaez | Story | 10 | Denmark | 11 |
| The Wounded Squirrel | 2021 | Maya Åstrup, Carmen Pérez | Story | 6 | Denmark | 11 |
| Freefall Vehicle | 2021 | Andreas Pihl, Massimo Fecchi | Story | 26 | Denmark | 11 |
| Moonlight Festival | 2021 | Gorm Transgaard, Carmen Pérez | Story | 10 | Denmark | 11 |
| Brigitta e l'affarone del pappa modo | 2021 | Augusto Macchetto, Valerio Held | Story | 24 | Italy | 11 |
| Paperino e il carillon proboscidato | 2021 | Rudy Salvagnini, Blasco Pisapia | Story | 20 | Italy | 11 |
| The Masked Knight | 2021 | Stefano Ambrosio, Lorenzo Pastrovicchio | Story | 22 | Disney Publishing Worldwide (global) | 11 |
| Scaldatorius the Dragon | 2021 | Stefano Ambrosio, Lorenzo Pastrovicchio | Story | 22 | Disney Publishing Worldwide (global) | 11 |
| The Curse of the Endless Rain | 2021 | Alessandro Gatti, Alessandro Pastrovicchio | Story | 22 | Disney Publishing Worldwide (global) | 11 |
| The Guardian of the Abyss | 2021 | Riccardo Pesce, Ciro Cangialosi | Story | 22 | Disney Publishing Worldwide (global) | 11 |
| The Tournament of the Medlar | 2021 | Alessandro Gatti, Marco Mazzarello | Story | 22 | Disney Publishing Worldwide (global) | 11 |
| The Lying Ballads | 2021 | Alessandro Gatti, Lorenzo Pastrovicchio | Story | 22 | Disney Publishing Worldwide (global) | 11 |
| The New Knight | 2021 | Alessandro Ferrari, Alessandro Pastrovicchio | Story | 22 | Disney Publishing Worldwide (global) | 11 |
| Just Ten Minutes | 2021 | Alessandro Ferrari, Marco Mazzarello | Story | 22 | Disney Publishing Worldwide (global) | 11 |
| The Garden Contest | 2021 | Bob Bartholomew, Beatriz Bolster | Story | 8 | Denmark | 10 |
| The Babysitter | 2021 | Gaute Moe, Francisco Rodriguez Peinado | Story | 4 | Denmark | 10 |
| Impossible Pet | 2021 | Gorm Transgaard, Sebastián Puñales | Story | 3 | Denmark | 10 |
| Donald Goes Viral | 2021 | Maya Åstrup, Francisco Rodriguez Peinado | Story | 10 | Denmark | 10 |
| The Thunder Storm | 2021 | Maya Åstrup, Maria José Sánchez Núñez | Story | 5 | Denmark | 10 |
| Untitled cover | 2021 | Maarten Gerritsen | Cover | 1 | Holland | 10 |
| Paperino e i ricordi perduti | 2021 | Gabriele Mazzoleni, Lara Molinari | Story | 18 | Italy | 10 |
| Retrogaming! | 2021 | Marco Nucci, Libero Ermetti | Story | 58 | Italy | 10 |
| Le orripilanti bomboniere di Pico de Paperis | 2021 | Francesco Vacca, Mattia Surroz | Story | 12 | Italy | 10 |
| A Day To Remember | 2021 | Alessandro Ferrari, Francesco D'Ippolito | Story | 22 | Disney Publishing Worldwide (global) | 10 |
| The First Date | 2021 | Alessandro Ferrari, Marco Mazzarello | Story | 22 | Disney Publishing Worldwide (global) | 10 |
| Green Thumb Code Red | 2021 | Chantal Pericoli, Marco Mazzarello | Story | 22 | Disney Publishing Worldwide (global) | 10 |
| Mysterious Digits | 2021 | Gaute Moe, Carmen Pérez | Story | 10 | Denmark | 9 |
| Prehistoric Trouble | 2021 | Sune Troelstrup, Wanda Gattino | Story | 10 | Denmark | 9 |
| Reality Bites | 2021 | Kari Korhonen | Story | 2 | Denmark | 9 |
| The Supernova | 2021 | Gaute Moe, Cèsar Ferioli Pelaez | Story | 10 | Denmark | 9 |
| Artistic Flair | 2021 | Jaakko Seppälä, Fernando Güell | Story | 3 | Denmark | 9 |