| Siamo serie! | 2021 | Sergio Badino, Silvia Ziche | Story | 100 | Italy | 52 |
| Zio Paperone e la ventiquattrore di Paperopoli | 2021 | Alessandro Sisti, Mario Ferracina | Story | 76 | Italy | 49 |
| Musicalisota | 2021 | Giorgio Salati, Nicolino Picone | Story | 166 | Italy | 30 |
| Gastone e la solitudine del quadrifoglio | 2021 | Marco Nucci, Stefano Zanchi | Story | 52 | Italy | 26 |
| A Christmas Coot | 2021 | Marco Nucci, Paolo Mottura | Story | 40 | Italy | 21 |
| The Wheel of Fate | 2021 | Peter Snejbjerg, Giorgio Cavazzano | Story | 30 | Denmark | 19 |
| Going for the Gold | 2021 | Sune Troelstrup, Massimo Fecchi | Story | 30 | Denmark | 18 |
| Burning Rubber in Monte Palma | 2021 | Andreas Pihl, Andrea Ferraris | Story | 30 | Denmark | 18 |
| The Noble Game | 2021 | Lars Jensen, Flemming Andersen | Story | 26 | Denmark | 17 |
| Calisota Summer Cup | 2021 | Marco Nucci, Stefano Intini | Story | 122 | Italy | 17 |
| Zio Paperone in: freddo, neve e pagine stampate | 2021 | Corrado Mastantuono | Story | 36 | Italy | 17 |
| Paperoga e la micro-focalizzazione | 2021 | Pietro Zemelo, Valerio Held | Story | 10 | Italy | 16 |
| Newton Pitagorico e il cammino del puma bianco | 2021 | Marco Nucci, Emmanuele Baccinelli | Story | 28 | Italy | 16 |
| Crime Wave | 2021 | Peter Snejbjerg, Fabrizio Petrossi | Story | 10 | Denmark | 14 |
| Filo & Brigitta e l'impresa spaziale | 2021 | Pier Giuseppe Giunta, Roberto Vian | Story | 20 | Italy | 14 |
| Zio Paperone in i paperi non cambiano | 2021 | Corrado Mastantuono | Story | 24 | Italy | 14 |
| Fitness e cocomeri | 2021 | Alessio Coppola | Story | 1 | Italy | 14 |
| Musica, Maestro! | 2021 | Giorgio Fontana, Donald Soffritti | Story | 12 | Italy | 14 |
| Heroes of the Myth | 2021 | Jaakko Seppälä, Francisco Rodriguez Peinado | Story | 10 | Denmark | 13 |
| Paperino e l'agognato condizionatore | 2021 | Bruno Sarda, Giampaolo Soldati | Story | 16 | Italy | 13 |
| Paperoga papero impeccabile | 2021 | Roberto Gagnor, Giampaolo Soldati | Story | 24 | Italy | 13 |
| C'è metodo e metodo | 2021 | Giorgio Fontana, Donald Soffritti | Story | 12 | Italy | 13 |
| Che tempo fa? | 2021 | Nicola Tosolini | Story | 1 | Italy | 12 |
| Pulizia nello sport | 2021 | Riccardo Secchi, Luca Bonardi | Story | 1 | Italy | 12 |
| Paper Bat e la minaccia edulcorante | 2021 | Gabriele Mazzoleni, Francesco D'Ippolito | Story | 26 | Italy | 12 |
| Furto con destrezza | 2021 | Alessio Coppola | Story | 1 | Italy | 12 |
| Gastone e l'hotel di ghiaccio | 2021 | Bruno Sarda, Massimo Fecchi | Story | 26 | Italy | 11 |
| Paperi al supermercato | 2021 | Francesco Vacca, Giulia La Torre | Story | 12 | Italy | 11 |
| Paperino e il carillon proboscidato | 2021 | Rudy Salvagnini, Blasco Pisapia | Story | 20 | Italy | 11 |
| The Masked Knight | 2021 | Stefano Ambrosio, Lorenzo Pastrovicchio | Story | 22 | Disney Publishing Worldwide (global) | 11 |
| The Curse of the Endless Rain | 2021 | Alessandro Gatti, Alessandro Pastrovicchio | Story | 22 | Disney Publishing Worldwide (global) | 11 |
| The Guardian of the Abyss | 2021 | Riccardo Pesce, Ciro Cangialosi | Story | 22 | Disney Publishing Worldwide (global) | 11 |
| The Tournament of the Medlar | 2021 | Alessandro Gatti, Marco Mazzarello | Story | 22 | Disney Publishing Worldwide (global) | 11 |
| The Cauldron of Discord | 2021 | Riccardo Pesce, Luca Usai | Story | 22 | Disney Publishing Worldwide (global) | 11 |
| The Lying Ballads | 2021 | Alessandro Gatti, Lorenzo Pastrovicchio | Story | 22 | Disney Publishing Worldwide (global) | 11 |
| The New Knight | 2021 | Alessandro Ferrari, Alessandro Pastrovicchio | Story | 22 | Disney Publishing Worldwide (global) | 11 |
| The Thrill of the Night | 2021 | Maya Åstrup, Wanda Gattino | Story | 6 | Denmark | 10 |
| Paperino e i ricordi perduti | 2021 | Gabriele Mazzoleni, Lara Molinari | Story | 18 | Italy | 10 |
| Retrogaming! | 2021 | Marco Nucci, Libero Ermetti | Story | 58 | Italy | 10 |
| Le orripilanti bomboniere di Pico de Paperis | 2021 | Francesco Vacca, Mattia Surroz | Story | 12 | Italy | 10 |
| The Swimming Pool | 2021 | Gaute Moe, Flemming Andersen | Story | 1 | Denmark | 9 |
| A Day with Molly & May | 2021 | Lars Jensen, Maria José Sánchez Núñez | Story | 6 | Denmark | 9 |
| L'esperimento! | 2021 | Enrico Faccini | Story | 4 | Italy | 9 |
| Il barocco | 2021 | Augusto Macchetto, Emilio Urbano | Story | 27 | Italy | 8 |
| Paperoga e il mostro di puzza | 2021 | Marco Nucci, Nicola Tosolini | Story | 22 | Italy | 8 |
| Empire Battles | 2021 | Gaute Moe, Cynthia Campanario Pineda | Story | 4 | Denmark | 7 |
| A Piece of Cake | 2021 | Peter Snejbjerg, Wanda Gattino | Story | 10 | Denmark | 7 |
| L'ultima avventura di Reginella | 2021 | Alex Bertani, Stefano Zanchi | Story | 52 | Italy | 7 |
| Il film di paura | 2021 | Giulio D'Antona, Roberta Migheli | Story | 1 | Italy | 7 |
| Untitled illustration | 2021 | Fabio Celoni | Illustration | 1 | Italy | 7 |
| Untitled cover | 2021 | Alessandro Perina | Cover | 1 | Italy | 7 |
| Untitled cover | 2021 | Francesco D'Ippolito | Cover | 1 | Italy | 7 |
| Untitled cover | 2021 | Corrado Mastantuono | Cover | 1 | Italy | 7 |
| Topo Principe | 2021 | Augusto Macchetto, Giada Perissinotto | Story | 50 | Italy | 6 |
| Paperino pastore cittadino | 2021 | Marco Bosco, Pietro Zemelo | Story | 6 | Italy | 6 |
| Untitled cover | 2021 | | Cover | 1 | Denmark | 5 |
| ...a Paperopoli | 2021 | Silvia Ziche | Story | 1 | Italy | 5 |
| Newton Pitagorico in... sono solo pensieri | 2021 | Marco Nucci, Simona Capovilla | Story | 30 | Italy | 5 |
| Una leggenda ...smisurata | 2021 | Alessio Coppola | Story | 1 | Italy | 5 |
| Untitled cover | 2021 | Diego Bernardo | Cover | 1 | Denmark | 4 |