| The Bar None Ranch | 1959 | Merrill De Maris, Paul Murry | Story | 40 | Western | 138 |
| Topolino e la dimensione Delta | 1959 | Romano Scarpa | Story | 72 | Italy | 69 |
| With Uncle Mukluk | 1959 | Carl Fallberg, Paul Murry | Story | 6 | Western | 61 |
| The Moose Head Mystery | 1959 | Nick George, Paul Murry | Story | 14 | Western | 54 |
| D'Artagnan 1959... | 1959 | Pierre Fallot, Pierre Nicolas | Story | 11 | France | 50 |
| Troubled Trouble Shooter | 1959 | Paul Murry | Story | 5 | Western | 49 |
| Grab Bag Bird | 1959 | Paul Murry | Story | 6 | Western | 47 |
| Paperino e l'oro di Reno ovvero L'anello dei nani lunghi | 1959 | Guido Martina, Pier Lorenzo De Vita | Story | 80 | Italy | 35 |
| Happy Birthday | 1959 | Paul Murry | Story | 1 | Western | 29 |
| Swamp Safari | 1959 | Jack Bradbury | Story | 7 | Western | 26 |
| Cloak And Rope Dragger | 1959 | Tony Strobl | Story | 7 | Western | 24 |
| Untitled newspaper strip | 1959 | Bill Walsh, Manuel Gonzales | Newspaper strip | 1 | Sunday pages (US) | 23 |
| Untitled cover | 1959 | Tony Strobl | Cover | 1 | Western | 19 |
| Untitled newspaper strip | 1959 | Bill Walsh, Manuel Gonzales | Newspaper strip | 1 | Sunday pages (US) | 19 |
| Topolino e il ritorno dell'artiglio magnetico | 1959 | Guido Martina, Giulio Chierchini | Story | 82 | Italy | 18 |
| Topolino e la stella dello sceriffo | 1959 | Gian Giacomo Dalmasso, Pier Lorenzo De Vita | Story | 45 | Italy | 17 |
| Untitled newspaper strip | 1959 | Bill Walsh, Manuel Gonzales | Newspaper strip | 1 | Sunday pages (US) | 17 |
| Untitled newspaper strip | 1959 | Bill Walsh, Manuel Gonzales | Newspaper strip | 1 | Sunday pages (US) | 16 |
| Sub Safari | 1959 | Tony Strobl | Story | 7 | Western | 15 |
| Untitled cover | 1959 | Donald T. MacLaughlin | Cover | 1 | Western | 15 |
| Untitled newspaper strip | 1959 | Bill Walsh, Manuel Gonzales | Newspaper strip | 1 | Sunday pages (US) | 14 |
| Miki y Pluto | 1959 | Paul Murry | Story | 1 | Western | 13 |
| Untitled cover | 1959 | Tony Strobl | Cover | 1 | Western | 12 |
| Gifts for the Gang | 1959 | Tony Strobl | Illustration | 1 | Western | 11 |
| Minnie's spiral Christmas tree | 1959 | Tony Strobl | Illustration | 1 | Western | 11 |
| Untitled newspaper strip | 1959 | Bill Walsh, Manuel Gonzales | Newspaper strip | 1 | Sunday pages (US) | 11 |
| Untitled newspaper strip | 1959 | Bill Walsh, Manuel Gonzales | Newspaper strip | 1 | Sunday pages (US) | 10 |
| Untitled newspaper strip | 1959 | Bill Walsh, Manuel Gonzales | Newspaper strip | 1 | Sunday pages (US) | 10 |
| Untitled newspaper strip | 1959 | Bill Walsh, Manuel Gonzales | Newspaper strip | 1 | Sunday pages (US) | 10 |
| Untitled newspaper strip | 1959 | Bill Walsh, Manuel Gonzales | Newspaper strip | 1 | Sunday pages (US) | 9 |
| Untitled newspaper strip | 1959 | Bill Walsh, Manuel Gonzales | Newspaper strip | 1 | Sunday pages (US) | 9 |
| Pluto's Problem | 1959 | Tony Strobl | Text story | 1 | Western | 8 |
| Untitled newspaper strip | 1959 | Roy Williams, Julius Svendsen | Newspaper strip | 1 | Daily strips (US) | 8 |
| Untitled newspaper strip | 1959 | Roy Williams, Julius Svendsen | Newspaper strip | 1 | Daily strips (US) | 8 |
| Topolino e il panettone dell'imperatore | 1959 | Guido Martina, Giulio Chierchini | Story | 43 | Italy | 7 |
| Mickey's Summer Time | 1959 | Tony Strobl | Game or puzzle | 1 | Western | 7 |
| Untitled newspaper strip | 1959 | Milt Banta, Manuel Gonzales | Newspaper strip | 1 | Daily strips (US) | 7 |
| Untitled newspaper strip | 1959 | Milt Banta, Riley Thomson | Newspaper strip | 1 | Daily strips (US) | 7 |
| Untitled newspaper strip | 1959 | Bill Walsh, Floyd Gottfredson | Newspaper strip | 1 | Daily strips (US) | 7 |
| Beach Party Treats | 1959 | Tony Strobl | Game or puzzle | 1 | Western | 6 |
| The Reckless Rockets | 1959 | Tony Strobl | Text story | 1 | Western | 6 |
| Untitled newspaper strip | 1959 | Milt Banta, Riley Thomson | Newspaper strip | 1 | Daily strips (US) | 6 |
| Untitled newspaper strip | 1959 | Milt Banta, Riley Thomson | Newspaper strip | 1 | Daily strips (US) | 6 |
| Untitled newspaper strip | 1959 | Milt Banta, Riley Thomson | Newspaper strip | 1 | Daily strips (US) | 6 |
| Untitled newspaper strip | 1959 | Roy Williams, Julius Svendsen | Newspaper strip | 1 | Daily strips (US) | 6 |
| Untitled newspaper strip | 1959 | Roy Williams, Julius Svendsen | Newspaper strip | 1 | Daily strips (US) | 6 |
| Untitled newspaper strip | 1959 | Roy Williams, Julius Svendsen | Newspaper strip | 1 | Daily strips (US) | 6 |
| Papai Noel Por Acaso | 1959 | Jorge Kato | Story | 12 | Brazil | 5 |
| Untitled newspaper strip | 1959 | Milt Banta, Riley Thomson | Newspaper strip | 1 | Daily strips (US) | 5 |
| Untitled newspaper strip | 1959 | Milt Banta, Riley Thomson | Newspaper strip | 1 | Daily strips (US) | 5 |
| Untitled newspaper strip | 1959 | Milt Banta, Riley Thomson | Newspaper strip | 1 | Daily strips (US) | 5 |
| Untitled newspaper strip | 1959 | Milt Banta, Riley Thomson | Newspaper strip | 1 | Daily strips (US) | 5 |
| Untitled newspaper strip | 1959 | Roy Williams, Julius Svendsen | Newspaper strip | 1 | Daily strips (US) | 5 |
| Untitled newspaper strip | 1959 | Roy Williams, Julius Svendsen | Newspaper strip | 1 | Daily strips (US) | 5 |
| Untitled newspaper strip | 1959 | Roy Williams, Julius Svendsen | Newspaper strip | 1 | Daily strips (US) | 5 |
| Untitled newspaper strip | 1959 | Roy Williams, Julius Svendsen | Newspaper strip | 1 | Daily strips (US) | 5 |
| Untitled newspaper strip | 1959 | Bill Walsh, Floyd Gottfredson | Newspaper strip | 1 | Daily strips (US) | 5 |
| Untitled newspaper strip | 1959 | Bill Walsh, Floyd Gottfredson | Newspaper strip | 1 | Daily strips (US) | 5 |
| Untitled newspaper strip | 1959 | Bill Walsh, Manuel Gonzales | Newspaper strip | 1 | Sunday pages (US) | 5 |
| Untitled newspaper strip | 1959 | Bill Walsh, Manuel Gonzales | Newspaper strip | 1 | Sunday pages (US) | 5 |