| Dr. X | 1955 | Bill Walsh, Floyd Gottfredson | Newspaper strip | 121 | Daily strips (US) | 672 |
| Race for Riches | 1935 | Ted Osborne, Floyd Gottfredson | Newspaper strip | 102 | Daily strips (US) | 639 |
| Mickey Mouse Sails for Treasure Island | 1932 | Floyd Gottfredson | Newspaper strip | 155 | Daily strips (US) | 582 |
| Outwits the Phantom Blot | 1939 | Merrill De Maris, Floyd Gottfredson | Newspaper strip | 97 | Daily strips (US) | 492 |
| His Horse Tanglefoot | 1933 | Ted Osborne, Floyd Gottfredson | Newspaper strip | 102 | Daily strips (US) | 491 |
| The Crazy Crime Wave | 1933 | Merrill De Maris, Floyd Gottfredson | Newspaper strip | 80 | Daily strips (US) | 475 |
| The Mighty Whale Hunter | 1938 | Merrill De Maris, Floyd Gottfredson | Newspaper strip | 125 | Daily strips (US) | 470 |
| Bobo the Elephant | 1934 | Ted Osborne, Floyd Gottfredson | Newspaper strip | 66 | Daily strips (US) | 443 |
| Goofy and Agnes | 1942 | Merrill De Maris, Floyd Gottfredson | Newspaper strip | 90 | Daily strips (US) | 443 |
| The Atombrella and the Rhyming Man | 1948 | Bill Walsh, Floyd Gottfredson | Newspaper strip | 140 | Daily strips (US) | 430 |
| The Sacred Jewel | 1934 | Ted Osborne, Floyd Gottfredson | Newspaper strip | 66 | Daily strips (US) | 425 |
| The Robin Hood Adventure | 1936 | Ted Osborne, Floyd Gottfredson | Newspaper strip | 24 | Sunday pages (US) | 402 |
| An Education for Thursday | 1940 | Merrill De Maris, Floyd Gottfredson | Newspaper strip | 84 | Daily strips (US) | 394 |
| The Bat Bandit of Inferno Gulch | 1934 | Ted Osborne, Floyd Gottfredson | Newspaper strip | 78 | Daily strips (US) | 386 |
| The Man of Tomorrow | 1947 | Bill Walsh, Floyd Gottfredson | Newspaper strip | 84 | Daily strips (US) | 382 |
| The Great Orphanage Robbery | 1932 | Floyd Gottfredson | Newspaper strip | 108 | Daily strips (US) | 376 |
| Mickey Mouse and the Gypsies | 1931 | Floyd Gottfredson | Newspaper strip | 96 | Daily strips (US) | 362 |
| Mickey Takes Umbrage | 1953 | Bill Walsh, Floyd Gottfredson | Newspaper strip | 81 | Daily strips (US) | 356 |
| Alla ricerca della pietra zodiacale | 1990 | Bruno Sarda, Franco Valussi | Story | 347 | Italy | 355 |
| Wizards of Mickey | 2006 | Stefano Ambrosio, Alessandro Perina | Story | 266 | Italy | 351 |
| Blaggard Castle | 1932 | Webb Smith, Floyd Gottfredson | Newspaper strip | 78 | Daily strips (US) | 348 |
| The Kid Gang | 1954 | Bill Walsh, Floyd Gottfredson | Newspaper strip | 108 | Daily strips (US) | 345 |
| A Fatal Occupation | 1954 | Bill Walsh, Floyd Gottfredson | Newspaper strip | 90 | Daily strips (US) | 322 |
| Uncle Gudger | 1954 | Bill Walsh, Floyd Gottfredson | Newspaper strip | 89 | Daily strips (US) | 318 |
| The Pirate Ghostship | 1944 | Bill Walsh, Floyd Gottfredson | Newspaper strip | 78 | Daily strips (US) | 305 |
| Hoppy the Kangaroo | 1935 | Ted Osborne, Floyd Gottfredson | Newspaper strip | 18 | Sunday pages (US) | 298 |
| Untitled illustration | 2022 | Andrea Freccero | Illustration | | Italy | 287 |
| Billy, The Mouse | 1945 | Bill Walsh, Floyd Gottfredson | Newspaper strip | 90 | Daily strips (US) | 285 |
| The Brave Little Tailor | 1938 | Merrill De Maris, Floyd Gottfredson | Newspaper strip | 14 | Sunday pages (US) | 269 |
| Mickey's Nephews | 1932 | Floyd Gottfredson | Newspaper strip | 8 | Sunday pages (US) | 250 |
| Dr. Oofgay's Secret Serum | 1934 | Ted Osborne, Floyd Gottfredson | Newspaper strip | 13 | Sunday pages (US) | 246 |
| Pluto the Racer | 1934 | Ted Osborne, Floyd Gottfredson | Newspaper strip | 54 | Daily strips (US) | 243 |
| Mother Pluto | 1938 | Merrill De Maris, Al Taliaferro | Newspaper strip | 10 | Sunday pages (US) | 239 |
| The World of Tomorrow | 1944 | Bill Walsh, Floyd Gottfredson | Newspaper strip | 90 | Daily strips (US) | 236 |
| Hoosat from Another Planet | 1952 | Bill Walsh, Floyd Gottfredson | Newspaper strip | 128 | Daily strips (US) | 235 |
| (Il segreto del totem decapitato) | 1973 | Guido Martina, Giovan Battista Carpi | Story | 241 | Italy | 224 |
| L'età oscura | 2007 | Stefano Ambrosio, Alessandro Perina | Story | 288 | Italy | 217 |
| Pflip's Strange Power | 1948 | Bill Walsh, Floyd Gottfredson | Newspaper strip | 60 | Daily strips (US) | 215 |
| The Magic Shoe | 1953 | Bill Walsh, Bill Wright | Newspaper strip | 111 | Daily strips (US) | 213 |
| Untitled illustration | 1999 | Lorenzo Pastrovicchio | Illustration | 2 | Italy | 211 |
| Mickey's Dangerous Double | 1953 | Bill Walsh, Floyd Gottfredson | Newspaper strip | 96 | Daily strips (US) | 201 |
| Li'l Davy | 1955 | Bill Walsh, Floyd Gottfredson | Newspaper strip | 86 | Daily strips (US) | 196 |
| The 'Lectro Box | 1943 | Bill Walsh, Floyd Gottfredson | Newspaper strip | 90 | Daily strips (US) | 192 |
| Circus Roustabout | 1931 | Floyd Gottfredson | Newspaper strip | 33 | Daily strips (US) | 188 |
| Clarabelle's Boarding House | 1931 | Floyd Gottfredson | Newspaper strip | 35 | Daily strips (US) | 181 |
| The Midas Ring | 1952 | Bill Walsh, Floyd Gottfredson | Newspaper strip | 76 | Daily strips (US) | 181 |
| Mighty Whale Hunter | 1950 | Merrill De Maris, Bill Wright | Story | 66 | Western | 167 |
| The Case of the Vanishing Coats | 1935 | Ted Osborne, Floyd Gottfredson | Newspaper strip | 6 | Sunday pages (US) | 166 |
| Battle the Giant Ants | 1950 | Bill Wright | Story | 25 | Western | 164 |
| Unhappy Campers | 1939 | Merrill De Maris, Floyd Gottfredson | Newspaper strip | 31 | Daily strips (US) | 159 |
| The House of Mystery | 1944 | Bill Walsh, Dick Moores | Newspaper strip | 66 | Daily strips (US) | 159 |
| Mickey's Pet Shop | 1947 | Bill Walsh, Floyd Gottfredson | Newspaper strip | 12 | Daily strips (US) | 157 |
| The Ventriloquist | 1936 | Ted Osborne, Floyd Gottfredson | Newspaper strip | 5 | Sunday pages (US) | 150 |
| Fireman Mickey | 1931 | Floyd Gottfredson | Newspaper strip | 19 | Daily strips (US) | 144 |
| Mickey Makes a Killing | 1947 | Bill Walsh, Floyd Gottfredson | Newspaper strip | 36 | Daily strips (US) | 141 |
| Outwits the Phantom Blot | 1949 | Merrill De Maris, Bill Wright | Story | 48 | Western | 136 |
| Les mystères de la Tour Eiffel | 1950 | André-Paul Duchâteau, Tenas | Story | 34 | Belgium | 136 |
| The Mystery of the Robot Army! | 1951 | Stan Walsh | Story | 45 | Western | 132 |
| Dan, the Dogcatcher | 1932 | Floyd Gottfredson | Newspaper strip | 5 | Sunday pages (US) | 132 |
| L'inferno di Topolino | 1949 | Guido Martina, Angelo Bioletto | Story | 69 | Italy | 127 |