| Topolino e la vendetta fallita | 1981 | Gian Giacomo Dalmasso, Sergio Asteriti | Story | 24 | Italy | 27 |
| Topolino e l'enigma della piramide | 1981 | Osvaldo Pavese, Luciano Gatto | Story | 25 | Italy | 25 |
| The Angry Bank-Manager | 1981 | Jim Kenner, Antoni Bancells Pujadas | Story | 22 | Denmark | 24 |
| A Fonte da Juventude | 1981 | Ivan Saidenberg, Roberto O. Fukue | Story | 14 | Brazil | 19 |
| The Surprise Guest | 1981 | Romano Scarpa | Story | 16 | Disney Studio (foreign market stories) | 19 |
| Topolino e il mistero della doppia scomparsa | 1981 | Filadelfo Amato, Sergio Asteriti | Story | 26 | Italy | 18 |
| Clarabelle, Superstar | 1981 | Les Lilley, Antoni Bancells Pujadas | Story | 5 | Denmark | 17 |
| Στα ίχνη των έξι! | 1981 | | Game or puzzle | 1 | Germany | 17 |
| The Vegetrouble Garden | 1981 | Jack Bradbury, Jaime Diaz Studio | Story | 9 | Disney Studio (foreign market stories) | 16 |
| The Sweet Smell Of Success | 1981 | Greg Crosby, Jaime Diaz Studio | Story | 15 | Disney Studio (foreign market stories) | 16 |
| Super Goof The Hiker | 1981 | Les Lilley, Josep Tello Gonzalez | Story | 7 | Denmark | 15 |
| Untitled cover | 1981 | | Cover | 1 | Denmark | 15 |
| Zio Paperone e il pomo della discordia | 1981 | Guido Martina, Guido Scala | Story | 32 | Italy | 15 |
| Topolino e l'occhio del drago | 1981 | Filadelfo Amato, Luciano Gatto | Story | 22 | Italy | 15 |
| Keeping Your Balance! | 1981 | Jim Kenner, Pepe Ferré | Story | 1 | Denmark | 14 |
| Pearly Parlance | 1981 | Jack Sutter, Antoni Bancells Pujadas | Story | 7 | Denmark | 14 |
| Topolino e lo scacco matto al Luna Park | 1981 | Bruno Concina, Cèsar Ferioli Pelaez | Story | 25 | Italy | 14 |
| Topolino e il ladro di gloria | 1981 | Andrea Mantelli, Alberico Motta | Story | 24 | Italy | 14 |
| Minnie Mouse And The Monkey Frogs | 1981 | Ed Nofziger, Owen Fitzgerald | Story | 12 | Disney Studio (foreign market stories) | 14 |
| Sold In The Big Top | 1981 | Jack Bradbury, Jaime Diaz Studio | Story | 14 | Disney Studio (foreign market stories) | 14 |
| Jungle Princess | 1981 | Howard Swift, Jaime Diaz Studio | Story | 11 | Disney Studio (foreign market stories) | 14 |
| Untitled newspaper strip | 1981 | Del Connell, Manuel Gonzales | Newspaper strip | 1 | Sunday pages (US) | 14 |
| Untitled newspaper strip | 1981 | Del Connell, Daan Jippes | Newspaper strip | 1 | Sunday pages (US) | 14 |
| Untitled cover | 1981 | Josep Tello Gonzalez | Cover | 1 | Denmark | 13 |
| Topolino e la faccenda Goldenbroc | 1981 | Erasmo Buzzacchi, Sergio Asteriti | Story | 31 | Italy | 13 |
| The Not-too-welcome Guest | 1981 | Jack Bradbury, Jaime Diaz Studio | Story | 9 | Disney Studio (foreign market stories) | 13 |
| Good Skate Delivery | 1981 | Ed Nofziger, Jaime Diaz Studio | Story | 10 | Disney Studio (foreign market stories) | 13 |
| Topolino e il nasino francese | 1981 | Bruno Concina, Cèsar Ferioli Pelaez | Story | 31 | Italy | 12 |
| Let Me Pay | 1981 | Ed Nofziger, Jaime Diaz Studio | Story | 11 | Disney Studio (foreign market stories) | 12 |
| Topolino e la fossa delle Susanne | 1981 | Caterina Mognato, Francesc Bargadà Studio | Story | 27 | Italy | 11 |
| The Showoffs | 1981 | Jack Bradbury, Jaime Diaz Studio | Story | 9 | Disney Studio (foreign market stories) | 11 |
| Untitled newspaper strip | 1981 | Del Connell, Tony Strobl | Newspaper strip | 1 | Sunday pages (US) | 11 |
| Spare The Good Advice! | 1981 | Jim Kenner, Antoni Bancells Pujadas | Story | 6 | Denmark | 10 |
| 古堡迷宫 | 1981 | | Game or puzzle | 1 | Germany | 10 |
| Topolino e la pianta prodigiosa | 1981 | Gian Giacomo Dalmasso, Giulio Chierchini | Story | 30 | Italy | 10 |
| In regalo, speciale musica e hi-fi | 1981 | Marco Rota | Cover | 1 | Italy | 10 |
| Clarabelle's Golden Voice | 1981 | Ed Nofziger, Jaime Diaz Studio | Story | 10 | Disney Studio (foreign market stories) | 10 |
| Untitled newspaper strip | 1981 | Del Connell, Daan Jippes | Newspaper strip | 1 | Sunday pages (US) | 10 |
| Enjoy Your Day | 1981 | Ed Nofziger, Jaime Diaz Studio | Story | 10 | Disney Studio (foreign market stories) | 9 |
| Untitled newspaper strip | 1981 | Del Connell, Román Arámbula | Newspaper strip | 1 | Daily strips (US) | 9 |
| Summer Drive | 1981 | Jim Kenner, Antoni Bancells Pujadas | Story | 4 | Denmark | 8 |
| Topolino e il critico scomparso | 1981 | Rudy Salvagnini, Alberico Motta | Story | 26 | Italy | 8 |
| Junk Is Keen Stuff | 1981 | Jack Bradbury, Jaime Diaz Studio | Story | 11 | Disney Studio (foreign market stories) | 8 |
| The Churn Turns | 1981 | Howard Swift, Jaime Diaz Studio | Story | 9 | Disney Studio (foreign market stories) | 8 |
| Friends Indeed | 1981 | Ed Nofziger, Jaime Diaz Studio | Story | 12 | Disney Studio (foreign market stories) | 8 |
| Untitled newspaper strip | 1981 | Del Connell, Daan Jippes | Newspaper strip | 1 | Sunday pages (US) | 8 |
| Dubbelgangers | 1981 | | Game or puzzle | 1 | Germany | 7 |
| Domino | 1981 | | Game or puzzle | 1 | Germany | 7 |
| Untitled game or puzzle | 1981 | | Game or puzzle | 1 | Germany | 7 |
| Η εύθυμη σελίδα μας! | 1981 | | Game or puzzle | 1 | Germany | 7 |
| Untitled newspaper strip | 1981 | Del Connell, Román Arámbula | Newspaper strip | 1 | Daily strips (US) | 7 |
| Untitled newspaper strip | 1981 | Del Connell, Tony Strobl | Newspaper strip | 1 | Sunday pages (US) | 7 |
| Untitled newspaper strip | 1981 | Del Connell, Daan Jippes | Newspaper strip | 1 | Sunday pages (US) | 7 |
| Der Vertrauensposten | 1981 | Del Connell | Story | <1 | Denmark | 6 |
| Untitled cover | 1981 | | Cover | 1 | Denmark | 6 |
| 7ème manuel des Castors Juniors | 1981 | Antoine Icart | Text story | 178 | France | 6 |
| Portrettenprobleem | 1981 | | Game or puzzle | 1 | Germany | 6 |
| Η εύθυμη σελίδα μας! | 1981 | | Game or puzzle | 1 | Germany | 6 |
| Kuis Minum Teh | 1981 | | Game or puzzle | 1 | Germany | 6 |
| Ferien-Poster | 1981 | | Illustration | 8 | Germany | 6 |