| History Re-Petes Itself | 2000 | David Gerstein, Romano Scarpa | Story | 12 | Denmark | 43 |
| Go Figure! | 2000 | Sarah Kinney, Francisco Rodriguez Peinado | Story | 8 | Denmark | 39 |
| Pluto's Christmas Tree | 2000 | Kari Korhonen, Francisco Rodriguez Peinado | Story | 8 | Denmark | 39 |
| Once Upon A Dog | 2000 | Byron Erickson, Cèsar Ferioli Pelaez | Story | 12 | Denmark | 33 |
| The Bermuda Triangle Amusement Park | 2000 | Stefan Petrucha, Xavier Vives Mateu | Story | 17 | Denmark | 32 |
| Danger in the Darkroom | 2000 | Dave Rawson, Noel Van Horn | Story | 11 | Denmark | 28 |
| What's the Buzz? | 2000 | Stefan Petrucha, Xavier Vives Mateu | Story | 10 | Denmark | 27 |
| Topolino e Minni in una vacanza pericolosa | 2000 | Bruno Sarda, Giuseppe Dalla Santa | Story | 42 | Italy | 27 |
| Pop Goes The Pizza Place | 2000 | Stefan Petrucha, Xavier Vives Mateu | Story | 8 | Denmark | 26 |
| Topolino e l'anello d'oro di Atlantide | 2000 | Francesco Artibani, Claudio Sciarrone | Story | 100 | Italy | 26 |
| Topolino e l'ultimo dei Mohigatti | 2000 | Sisto Nigro, Graziano Barbaro | Story | 44 | Italy | 25 |
| Topolino e la notte dei Babbi Natale | 2000 | Silvio Camboni | Story | 32 | Italy | 25 |
| Unidentified Flying Horace | 2000 | Stefan Petrucha, Jorge David Redo | Story | 17 | Denmark | 24 |
| Whatever After | 2000 | Stefan Petrucha, Francisco Rodriguez Peinado | Story | 16 | Denmark | 24 |
| Time Marches Off | 2000 | Sarah Kinney, Francisco Rodriguez Peinado | Story | 11 | Denmark | 23 |
| Pinball Wizard | 2000 | Sarah Kinney, Jorge David Redo | Story | 7 | Denmark | 22 |
| Canus Cavalierus | 2000 | Peter Härdfeldt, Jorge David Redo | Story | 1 | Denmark | 20 |
| The No-Gun Kid! | 2000 | Michael T. Gilbert, Joaquín Cañizares Sanchez | Story | 35 | Denmark | 20 |
| 4 misteri per la Top Detectives | 2000 | Bruno Sarda, Lino Gorlero | Story | 110 | Italy | 20 |
| What's Happened to Clarabelle? | 2000 | Kristian Højsteen, Tino Santanach Hernandez | Story | 1 | Denmark | 19 |
| The Happy Feet | 2000 | Darko Macan, José Antonio González | Story | 35 | Denmark | 18 |
| Bargains at the Flea Market | 2000 | Kristian Højsteen, Tino Santanach Hernandez | Story | 1 | Denmark | 17 |
| Louse Of The Year | 2000 | Jeff Hamill, Cèsar Ferioli Pelaez | Story | 10 | Denmark | 17 |
| Topolino e il dominatore delle menti | 2000 | Carlo Panaro, Sergio Asteriti | Story | 34 | Italy | 17 |
| Le monstre de Halloween | 2000 | Fabien Vehlmann, Valentin Doménech | Story | 12 | France | 16 |
| Untitled cover | 2000 | Michel Nadorp | Cover | 1 | Holland | 16 |
| Minni e il giorno della Regina | 2000 | François Corteggiani, Roberto Ronchi | Story | 27 | Italy | 15 |
| Gambadilegno e il succo del terrore | 2000 | Fabio Michelini, Alessio Coppola | Story | 33 | Italy | 15 |
| Untitled article | 2000 | | Article | 1 | Brazil | 14 |
| Observations At The Observatory | 2000 | Kari Korhonen, Tino Santanach Hernandez | Story | 1 | Denmark | 14 |
| La grande delusione | 2000 | Giorgio Pezzin, Nicola Tosolini | Story | 33 | Italy | 14 |
| L'abominevole uovo delle nevi | 2000 | Rudy Salvagnini, Lorenzo Pastrovicchio | Story | 8 | Italy | 13 |
| Indiana Pipps e il tesoro dei cavalieri d'oriente | 2000 | Bruno Sarda, Roberto Vian | Story | 37 | Italy | 13 |
| Topolino e la crociera movimentata | 2000 | Bruno Sarda, Carlo Limido | Story | 32 | Italy | 13 |
| La ragione e il cuore | 2000 | Giorgio Pezzin, Ettore Gula | Story | 39 | Italy | 13 |
| Seafood Galore | 2000 | Werner Wejp-Olsen, Angel Rodriguez | Story | 4 | Denmark | 12 |
| Absolutely Mickey | 2000 | Stefan Petrucha, Miguel Fernández Martinez | Story | 37 | Denmark | 12 |
| Victoria | 2000 | Augusto Macchetto, Stefano Turconi | Story | 64 | Italy | 12 |
| Maestro in cucina | 2000 | Giulia Conti, Andrea Ferraris | Story | 1 | Italy | 12 |
| Minni, Tebel e il profumo della primavera | 2000 | Giustina Porcelli, Roberto Vian | Story | 23 | Italy | 11 |
| Minni giornata con...turbante | 2000 | Nino Russo, Marco Meloni | Story | 8 | Italy | 11 |
| C'era una volta Mickey Montana | 2000 | Stefano Ambrosio, Roberto Vian | Story | 46 | Italy | 11 |
| Di nuovo insieme | 2000 | Giorgio Pezzin, Graziano Barbaro | Story | 37 | Italy | 11 |
| Beach Bummer | 2000 | Janet Gilbert, Angel Rodriguez | Story | 4 | Denmark | 10 |
| Minni Crusoe pubblicitaria | 2000 | Paolo Campinoti, Roberta Zanotta | Story | 6 | Italy | 10 |
| Una giornata esagerata | 2000 | Gianluca Panniello, Donald Soffritti | Story | 25 | Italy | 10 |
| Untitled cover | 2000 | Corrado Mastantuono | Cover | 1 | Italy | 10 |
| Era uma vez... Margarida | 2000 | Francesco Artibani, Corrado Mastantuono | Cover | 1 | Italy | 10 |
| Les secrets de Dingo | 2000 | François Corteggiani, Rachid Nawa | Story | 12 | France | 9 |
| L'élu de Malgouvert | 2000 | François Corteggiani, Rachid Nawa | Story | 16 | France | 9 |
| ISOIN KIRJAIMIN JA TA-VU-TET-TU | 2000 | Dominique Nicolli, Gen-Clo | Story | 1 | France | 9 |
| Minni e la Stella del Bosco | 2000 | Carlo Panaro, Roberto Vian | Story | 25 | Italy | 9 |
| Topolino e la vendetta di Luther Blot | 2000 | Gianfranco Cordara, Giuseppe Dalla Santa | Story | 46 | Italy | 9 |
| Topolino e il colpo di fulmine | 2000 | Gaja Arrighini, Carlo Limido | Story | 36 | Italy | 9 |
| Untitled cover | 2000 | Corrado Mastantuono | Cover | 1 | Italy | 9 |
| Untitled cover | 2000 | Francesco Artibani, Corrado Mastantuono | Cover | 1 | Italy | 9 |
| The Cult of Horace | 2000 | Stefan Petrucha, Jorge David Redo | Story | 10 | Denmark | 8 |
| Une énigme brillante ! | 2000 | Claude Turier, Rachid Nawa | Story | 1 | France | 8 |
| Différences | 2000 | Philippe Larbier | Game or puzzle | 1 | France | 8 |
| Jenny | 2000 | Nino Russo, Alessia Martusciello | Story | 23 | Italy | 8 |