| Paperino e l'incombenza natalizia | 2010 | Tito Faraci, Giampaolo Soldati | Story | 40 | Italy | 70 |
| Topolino e l'isola di Quandomai | 2010 | Casty | Story | 70 | Italy | 51 |
| Topolino e il mondo di Tutor | 2010 | Casty | Story | 61 | Italy | 51 |
| Cronache del regno dei due laghi | 2010 | Tito Faraci, Silvia Ziche | Story | 58 | Italy | 34 |
| Topolino e la leggenda del Topo Nero | 2010 | Giorgio Salati, Massimo De Vita | Story | 33 | Italy | 25 |
| Catch As Catch Can | 2010 | Byron Erickson, Francisco Rodriguez Peinado | Story | 16 | Denmark | 24 |
| Topolinia 20802 (2) | 2010 | Alberto Savini, Casty | Story | 119 | Italy | 24 |
| Topolino e il vento di libertà | 2010 | Bruno Sarda, Massimo De Vita | Story | 34 | Italy | 23 |
| The Scrap Man Cometh | 2010 | Stefan Petrucha, Xavier Vives Mateu | Story | 6 | Denmark | 21 |
| Every Dog has His Day | 2010 | Maya Åstrup, Massimo Fecchi | Story | 30 | Denmark | 20 |
| Diving | 2010 | Lynne Gibbs, Miguel Fernández Martinez | Game or puzzle | 1 | Denmark | 20 |
| Topo-Lee e il segreto del dragone pensoso | 2010 | Rudy Salvagnini, Graziano Barbaro | Story | 32 | Italy | 20 |
| Winterzauber | 2010 | Andrea Freccero | Cover | 2 | Denmark | 19 |
| Gambadilegno e il blocco di Capodanno | 2010 | Alberto Savini, Corrado Mastantuono | Story | 28 | Italy | 19 |
| Indiana Pipps e l'enigma di "Vent'anni dopo" | 2010 | Bruno Sarda, Massimo De Vita | Story | 40 | Italy | 18 |
| Topolino e la crociera nera | 2010 | Silvia Ziche | Story | 60 | Italy | 18 |
| The Game Awaits | 2010 | Sarah Kinney, Joaquín Cañizares Sanchez | Story | 10 | Denmark | 17 |
| Virtually Yours | 2010 | Maya Åstrup, Fabrizio Petrossi | Story | 7 | Denmark | 17 |
| Memento | 2010 | Noel Van Horn | Story | 12 | Denmark | 17 |
| Basettoni e la festa dei cuori | 2010 | Augusto Macchetto, Giampaolo Soldati | Story | 25 | Italy | 17 |
| Topolino e la principessa del lago invisibile | 2010 | Rudy Salvagnini, Massimo De Vita | Story | 30 | Italy | 17 |
| Whitewash | 2010 | Noel Van Horn | Story | 10 | Denmark | 16 |
| The Future Present | 2010 | Maya Åstrup, Fabrizio Petrossi | Story | 10 | Denmark | 16 |
| Topolino e le bambole dagli occhi cangianti | 2010 | Rodolfo Cimino, Marco Palazzi | Story | 31 | Italy | 16 |
| Jungle Love | 2010 | Carol McGreal, José Antonio González | Story | 10 | Denmark | 15 |
| The Longest Night | 2010 | Maya Åstrup, Xavier Vives Mateu | Story | 8 | Denmark | 15 |
| Regn den ud | 2010 | | Game or puzzle | 1 | Denmark | 15 |
| Finale di campionato | 2010 | Teresa Radice, Stefano Turconi | Story | 31 | Italy | 14 |
| The River Run | 2010 | Carol McGreal, Angel Rodriguez | Story | 10 | Denmark | 13 |
| Flotsam | 2010 | Noel Van Horn | Story | 10 | Denmark | 13 |
| Tuscan Holiday | 2010 | Mette Hald, Miguel Fernández Martinez | Story | 1 | Denmark | 13 |
| Un ombrello, un cappello, un monello | 2010 | Teresa Radice, Stefano Turconi | Story | 27 | Italy | 13 |
| Crack is Whack | 2010 | Stefan Petrucha, Jorge David Redo | Story | 3 | Denmark | 12 |
| La perla del fiume | 2010 | Teresa Radice, Stefano Turconi | Story | 30 | Italy | 12 |
| Untitled illustration | 2010 | Floyd Gottfredson | Illustration | 1 | X | 12 |
| Pixie In Hand | 2010 | Sarah Kinney, Fabrizio Petrossi | Story | 10 | Denmark | 11 |
| The Picasso Painting | 2010 | Mette Hald, Miguel Fernández Martinez | Story | 1 | Denmark | 11 |
| Φεστιβάλ Μίκυ Μάους | 2010 | Corrado Mastantuono | Illustration | 1 | Non-Disney and/or non-comics | 11 |
| By the Book | 2010 | Sarah Kinney, Joaquín Cañizares Sanchez | Story | 16 | Denmark | 10 |
| Topolino, Minni e la città sempre accesa | 2010 | Alessandro Sisti, Lorenzo Pastrovicchio | Story | 30 | Italy | 10 |
| Topolino e Minni in muro contro muro | 2010 | Riccardo Secchi, Corrado Mastantuono | Story | 32 | Italy | 10 |
| The Bank Job | 2010 | Sarah Kinney, Jorge David Redo | Story | 7 | Denmark | 9 |
| Legend | 2010 | Noel Van Horn | Story | 10 | Denmark | 8 |
| Σπαζοκεφαλιά | 2010 | | Game or puzzle | 1 | Denmark | 8 |
| Zoek & Vind: Mooi muurtje | 2010 | Simone Ruitenbeek, Angel Rodriguez | Game or puzzle | 1 | Holland | 8 |
| Untitled cover | 2010 | | Cover | 1 | Italy | 8 |
| Untitled cover | 2010 | | Cover | 1 | Italy | 8 |
| Untitled cover | 2010 | | Cover | 1 | Italy | 8 |
| A Ilha de Quandomai | 2010 | Casty | Cover | 1 | Italy | 8 |
| Τον Ιούνιο σπέσιαλ ιστορίες στο Μίκυ Μάους | 2010 | Alessandro Perina | Illustration | 1 | Non-Disney and/or non-comics | 8 |
| Life Stinks | 2010 | Carol McGreal, Xavier Vives Mateu | Story | 6 | Denmark | 7 |
| City Lights and Sleepless Nights | 2010 | Maya Åstrup, Xavier Vives Mateu | Story | 10 | Denmark | 7 |
| The Safari Lodge | 2010 | Mette Hald, Miguel Fernández Martinez | Story | 1 | Denmark | 7 |
| Cat's Cradle | 2010 | Maya Åstrup, Angel Rodriguez | Story | 6 | Denmark | 7 |
| Σπαζοκεφαλιά | 2010 | | Game or puzzle | 1 | Denmark | 7 |
| ... a Topolinia | 2010 | Silvia Ziche | Story | 1 | Italy | 7 |
| Untitled cover | 2010 | | Cover | 1 | Italy | 7 |
| Untitled cover | 2010 | Jonathan H. Gray | Cover | 1 | X | 7 |
| Kerel 3000 | 2010 | Evert Geradts, Maximino Tortajada Aguilar | Story | 17 | Holland | 6 |
| Topolino e il torneo di sua maestà | 2010 | Sisto Nigro, Giampaolo Soldati | Story | 33 | Italy | 6 |