| Grosso guaio a Paperopoli | 2021 | Alex Bertani, Giuseppe Facciotto | Story | 84 | Italy | 47 |
| Ducktopia | 2021 | Francesco Artibani, Francesco D'Ippolito | Story | 96 | Italy | 33 |
| Il bianco e il nero | 2021 | Marco Nucci, Casty | Story | 90 | Italy | 31 |
| Topolino e lo strano caso di Villa Ghirlanda | 2021 | Blasco Pisapia | Story | 41 | Italy | 29 |
| Io sono Macchia Nera | 2021 | Marco Nucci, Casty | Story | 64 | Italy | 25 |
| Brivido a Beaver Gulch | 2021 | Marco Bosco, Marco Mazzarello | Story | 40 | Italy | 24 |
| Topolino e i Goof Viewer | 2021 | Giorgio Salati, Lucio Leoni | Story | 40 | Italy | 21 |
| Cronache degli antichi regni | 2021 | Alessandro Sisti, Francesco D'Ippolito | Story | 120 | Italy | 21 |
| Going for the Gold | 2021 | Sune Troelstrup, Massimo Fecchi | Story | 30 | Denmark | 18 |
| La ciurma del Sole Nero | 2021 | Marco Gervasio, Cristian Canfailla | Story | 98 | Italy | 18 |
| Topolino & Minni in: Qualcosa nella nebbia | 2021 | Pietro Zemelo, Davide Cesarello | Story | 46 | Italy | 18 |
| Meet the New Kids | 2021 | | Article | 1 | Disney Publishing Worldwide (global) | 18 |
| La macchia invisibile | 2021 | Matteo Venerus, Francesco D'Ippolito | Story | 48 | Italy | 17 |
| Topolino e i misteri di Mister MacGuffin | 2021 | Marco Nucci, Giampaolo Soldati | Story | 28 | Italy | 15 |
| The Nightmare Mystery | 2021 | Lars Jensen, Andrea Freccero | Story | 28 | Denmark | 14 |
| Pippo e la polka del fachiro | 2021 | Rudy Salvagnini, Blasco Pisapia | Story | 14 | Italy | 13 |
| The Return of Monty | 2021 | Maya Åstrup, Massimo Fecchi | Story | 7 | Denmark | 11 |
| Mr. Bubbles | 2021 | Lars Jensen, Francisco Rodriguez Peinado | Story | 2 | Denmark | 11 |
| Topolino e l'ombra di mister Vertigo | 2021 | Marco Nucci, Ottavio Panaro | Story | 54 | Italy | 11 |
| Il piano | 2021 | Gabriele Panini, Maurizio Amendola | Story | 6 | Italy | 11 |
| Topolino e l'ingombrante sgombero | 2021 | Davide Aicardi, Marco Mazzarello | Story | 20 | Italy | 11 |
| Just Ten Minutes | 2021 | Alessandro Ferrari, Marco Mazzarello | Story | 22 | Disney Publishing Worldwide (global) | 11 |
| A Day To Remember | 2021 | Alessandro Ferrari, Francesco D'Ippolito | Story | 22 | Disney Publishing Worldwide (global) | 10 |
| The First Date | 2021 | Alessandro Ferrari, Marco Mazzarello | Story | 22 | Disney Publishing Worldwide (global) | 10 |
| Green Thumb Code Red | 2021 | Chantal Pericoli, Marco Mazzarello | Story | 22 | Disney Publishing Worldwide (global) | 10 |
| The Purr-fect Hero | 2021 | Maya Åstrup, Cynthia Campanario Pineda | Story | 6 | Denmark | 9 |
| When The Principal's Away | 2021 | Chantal Pericoli, Marco Mazzarello | Story | 22 | Disney Publishing Worldwide (global) | 9 |
| System Error | 2021 | Alessandro Ferrari, Stefano Intini | Story | 22 | Disney Publishing Worldwide (global) | 9 |
| A Girlfriend For Goofy | 2021 | Alessandro Ferrari, Francesco D'Ippolito | Story | 22 | Disney Publishing Worldwide (global) | 9 |
| Untitled illustration | 2021 | Thierry Martin | Illustration | 2 | France | 8 |
| Goofy sport op strand | 2021 | Lotte Roep, Jordi Alfonso | Story | <1 | Holland | 8 |
| Untitled cover | 2021 | Maarten Gerritsen | Cover | 1 | Holland | 8 |
| Minni nella casa dei mille corvi | 2021 | Marco Nucci, Casty | Story | 34 | Italy | 8 |
| A Ilha dos Mistérios | 2021 | Lorenzo Pastrovicchio | Cover | 1 | Italy | 8 |
| Topolino nella terra dei meriteri | 2021 | Giuseppe Zironi | Story | 32 | Italy | 7 |
| Topolino, Pippo e la logica illogico-provvidenziale | 2021 | Giulio D'Antona, Luca Usai | Story | 36 | Italy | 7 |
| ...a Topolinia | 2021 | Silvia Ziche | Story | 1 | Italy | 7 |
| Mission Roaring Race Cars | 2021 | Riccardo Pesce, Giada Perissinotto | Story | 22 | Disney Publishing Worldwide (global) | 7 |
| Untitled cover | 2021 | Giada Perissinotto | Cover | 1 | Disney Publishing Worldwide (global) | 7 |
| Lost 't op - De vieze vuurtoren | 2021 | Jos Beekman, Jan-Roman Pikula | Story | 1 | Holland | 6 |
| Una nuova boutique | 2021 | Valentina Camerini, Marco Mazzarello | Story | 24 | Italy | 6 |
| ...a Topolinia | 2021 | Silvia Ziche | Story | 1 | Italy | 6 |
| Topolino e il triplo capodanno | 2021 | Giuseppe Zironi | Story | 32 | Italy | 6 |
| Jeu de 54 cartes | 2021 | Fabio Celoni | Illustration | 1 | Italy | 6 |
| Untitled cover | 2021 | Corrado Mastantuono | Cover | 1 | Italy | 6 |
| Untitled illustration | 2021 | | Illustration | <1 | Posters and other promotional material | 6 |
| Mickey et les mille Pat | 2021 | Jean-Luc Cornette, Thierry Martin | Story | 74 | France | 5 |
| Mickey et les mille Pat | 2021 | Thierry Martin | Cover | 1 | France | 5 |
| Joyeuses fêtes | 2021 | Fabrizio Petrossi | Cover | 1 | France | 5 |
| Lost 't op - De Purperen Scherf | 2021 | Jos Beekman, Jan-Roman Pikula | Story | 1 | Holland | 5 |
| Spookhuis in de sneeuw | 2021 | Frank Jonker, Thomas Cabellic | Story | 5 | Holland | 5 |
| Topolino e la vita selvaggia | 2021 | Giuseppe Zironi | Story | 30 | Italy | 5 |
| Untitled cover | 2021 | Andrea Freccero | Cover | 1 | Italy | 5 |
| Untitled cover | 2021 | Andrea Freccero | Cover | 1 | Italy | 5 |
| Mission Peak Danger | 2021 | Valentina Camerini, Giada Perissinotto | Story | 22 | Disney Publishing Worldwide (global) | 5 |
| Mission Spy Express | 2021 | Riccardo Pesce, Giada Perissinotto | Story | 22 | Disney Publishing Worldwide (global) | 5 |
| Mission Rogue Spy | 2021 | Valentina Camerini, Giada Perissinotto | Story | 22 | Disney Publishing Worldwide (global) | 5 |
| Mission Sabotage Jungle | 2021 | Riccardo Pesce, Giada Perissinotto | Story | 22 | Disney Publishing Worldwide (global) | 5 |
| Mission Cluck Cluck | 2021 | Riccardo Pesce, Giada Perissinotto | Story | 22 | Disney Publishing Worldwide (global) | 5 |
| Mission Spies From The past | 2021 | Valentina Camerini, Giada Perissinotto | Story | 22 | Disney Publishing Worldwide (global) | 5 |