| Il viaggio del dollaro d'argento | 2021 | Gabriele Panini, Alessandro Gottardo | Story | 30 | Italy | 52 |
| Grosso guaio a Paperopoli | 2021 | Alex Bertani, Giuseppe Facciotto | Story | 84 | Italy | 47 |
| Ducktopia | 2021 | Francesco Artibani, Francesco D'Ippolito | Story | 96 | Italy | 33 |
| Il bianco e il nero | 2021 | Marco Nucci, Casty | Story | 90 | Italy | 31 |
| Topolino e lo strano caso di Villa Ghirlanda | 2021 | Blasco Pisapia | Story | 41 | Italy | 29 |
| Tip & Tap e l'invasione dei droni | 2021 | Pietro Zemelo, Luca Usai | Story | 32 | Italy | 29 |
| Topolino, Pippo e la scalata del secolo | 2021 | Fausto Vitaliano, Paolo Mottura | Story | 37 | Italy | 27 |
| Io sono Macchia Nera | 2021 | Marco Nucci, Casty | Story | 64 | Italy | 25 |
| Brivido a Beaver Gulch | 2021 | Marco Bosco, Marco Mazzarello | Story | 40 | Italy | 24 |
| Topolino e i Goof Viewer | 2021 | Giorgio Salati, Lucio Leoni | Story | 40 | Italy | 21 |
| Cronache degli antichi regni | 2021 | Alessandro Sisti, Francesco D'Ippolito | Story | 120 | Italy | 21 |
| Topolino e il principe della menzogna | 2021 | Marco Nucci, Fabrizio Petrossi | Story | 128 | Italy | 20 |
| Going for the Gold | 2021 | Sune Troelstrup, Massimo Fecchi | Story | 30 | Denmark | 18 |
| Danger at Zero-Zero | 2021 | Lars Jensen, Andrea Ferraris | Story | 16 | Denmark | 18 |
| La ciurma del Sole Nero | 2021 | Marco Gervasio, Cristian Canfailla | Story | 98 | Italy | 18 |
| Topolino & Minni in: Qualcosa nella nebbia | 2021 | Pietro Zemelo, Davide Cesarello | Story | 46 | Italy | 18 |
| Meet the New Kids | 2021 | | Article | 1 | Disney Publishing Worldwide (global) | 18 |
| La macchia invisibile | 2021 | Matteo Venerus, Francesco D'Ippolito | Story | 48 | Italy | 17 |
| Calisota Summer Cup | 2021 | Marco Nucci, Stefano Intini | Story | 122 | Italy | 17 |
| Sabotage at Sea | 2021 | Lars Jensen, Francisco Rodriguez Peinado | Story | 10 | Denmark | 15 |
| Topolino e i misteri di Mister MacGuffin | 2021 | Marco Nucci, Giampaolo Soldati | Story | 28 | Italy | 15 |
| Topolino e il trionfo della macchia | 2021 | Alessandro Sisti, Blasco Pisapia | Story | 24 | Italy | 15 |
| The Nightmare Mystery | 2021 | Lars Jensen, Andrea Freccero | Story | 28 | Denmark | 14 |
| The 13th Labor of Heracles | 2021 | Jaakko Seppälä, Fabrizio Petrossi | Story | 10 | Denmark | 14 |
| Jeu de 54 cartes | 2021 | Fabio Celoni | Illustration | 1 | Italy | 14 |
| The Blot Task Force | 2021 | Paul Murry | Story | 8 | Denmark | 13 |
| Macchia Nera in: Semplice, pulito, diretto | 2021 | Marco Nucci, Nicola Tosolini | Story | 26 | Italy | 13 |
| Pippo e gli acquisti creativi | 2021 | Giorgio Fontana, Giulia La Torre | Story | 4 | Italy | 13 |
| Pippo e la polka del fachiro | 2021 | Rudy Salvagnini, Blasco Pisapia | Story | 14 | Italy | 13 |
| Untitled cover | 2021 | Giada Perissinotto | Cover | 1 | Italy | 13 |
| Untitled cover | 2021 | Francesco D'Ippolito | Cover | 1 | Italy | 13 |
| Paintjob | 2021 | Andreas Pihl, Maximino Tortajada Aguilar | Story | 6 | Denmark | 12 |
| The Wrath of Poseidon | 2021 | Jaakko Seppälä, Fabrizio Petrossi | Story | 7 | Denmark | 12 |
| Ripara lo steccato | 2021 | Marco Bosco, Giorgio Di Vita | Story | 6 | Italy | 12 |
| Topolino e la micio-minaccia | 2021 | Casty, Enrico Faccini | Story | 34 | Italy | 12 |
| The Return of Monty | 2021 | Maya Åstrup, Massimo Fecchi | Story | 7 | Denmark | 11 |
| Bubble Heads | 2021 | Andreas Pihl, Lourdes Rueda Sala | Story | 3 | Denmark | 11 |
| Pluto e l'equivoco felino | 2021 | Monica Manzoni, Luca Bonardi | Story | 6 | Italy | 11 |
| Pippo e il parente pedante | 2021 | Roberto Moscato, Lucio Leoni | Story | 12 | Italy | 11 |
| Topolino e l'ombra di mister Vertigo | 2021 | Marco Nucci, Ottavio Panaro | Story | 54 | Italy | 11 |
| Topolino e l'ingombrante sgombero | 2021 | Davide Aicardi, Marco Mazzarello | Story | 20 | Italy | 11 |
| Just Ten Minutes | 2021 | Alessandro Ferrari, Marco Mazzarello | Story | 22 | Disney Publishing Worldwide (global) | 11 |
| A Safe Boat Ride | 2021 | Jack Sutter, Antoni Bancells Pujadas | Story | 10 | Denmark | 10 |
| Starstruck Dog | 2021 | Sune Troelstrup, Fabrizio Petrossi | Story | 5 | Denmark | 10 |
| Watch the Birdie | 2021 | Carol McGreal, Lourdes Rueda Sala | Story | 4 | Denmark | 10 |
| The Big Foot Beliver | 2021 | Stefan Printz-Påhlson, Francisco Rodriguez Peinado | Story | 5 | Denmark | 10 |
| Een schimmig antiekzaakje | 2021 | Robbert Damen, Thomas Cabellic | Story | 6 | Holland | 10 |
| Untitled illustration | 2021 | Andrea Freccero | Illustration | 1 | Italy | 10 |
| 19.999 Léguas Submarinas | 2021 | Lorenzo Pastrovicchio | Cover | 1 | Italy | 10 |
| A Day To Remember | 2021 | Alessandro Ferrari, Francesco D'Ippolito | Story | 22 | Disney Publishing Worldwide (global) | 10 |
| The First Date | 2021 | Alessandro Ferrari, Marco Mazzarello | Story | 22 | Disney Publishing Worldwide (global) | 10 |
| Green Thumb Code Red | 2021 | Chantal Pericoli, Marco Mazzarello | Story | 22 | Disney Publishing Worldwide (global) | 10 |
| The Purr-fect Hero | 2021 | Maya Åstrup, Cynthia Campanario Pineda | Story | 6 | Denmark | 9 |
| Run Tracker | 2021 | Jaakko Seppälä, Daan Jippes | Story | 1 | Denmark | 9 |
| Untitled cover | 2021 | Andrea Freccero | Cover | 1 | Denmark | 9 |
| Babbeltrucs | 2021 | Frank Jonker, Massimo Fecchi | Story | 4 | Holland | 9 |
| Pippo e il successino del cibo tiepidino | 2021 | Giorgio Fontana, Gigi Piras | Story | 6 | Italy | 9 |
| Untitled illustration | 2021 | Blasco Pisapia | Illustration | 1 | Italy | 9 |
| When The Principal's Away | 2021 | Chantal Pericoli, Marco Mazzarello | Story | 22 | Disney Publishing Worldwide (global) | 9 |
| A Grown-Up Vacation | 2021 | Alessandro Ferrari, Marco Mazzarello | Story | 22 | Disney Publishing Worldwide (global) | 9 |