| Pluto's Christmas Tree | 2000 | Kari Korhonen, Francisco Rodriguez Peinado | Story | 8 | Denmark | 39 |
| Once Upon A Dog | 2000 | Byron Erickson, Cèsar Ferioli Pelaez | Story | 12 | Denmark | 33 |
| Mush Mouse | 2000 | Carol McGreal, Francisco Rodriguez Peinado | Story | 10 | Denmark | 32 |
| Κόμιξ | 2000 | Bill Wright | Illustration | 1 | Non-Disney and/or non-comics | 31 |
| The Goofy Channel | 2000 | Sarah Kinney, Francisco Rodriguez Peinado | Story | 10 | Denmark | 30 |
| The Great Indian Rope Trick | 2000 | Peter Härdfeldt | Story | 10 | Denmark | 27 |
| What's the Buzz? | 2000 | Stefan Petrucha, Xavier Vives Mateu | Story | 10 | Denmark | 27 |
| Over-Eega Retriever | 2000 | Dave Rawson, Cèsar Ferioli Pelaez | Story | 10 | Denmark | 23 |
| We droomden dat... we op een boerderij woonden! | 2000 | Wilma van den Bosch | Centrefold or poster | 2 | Holland | 23 |
| We droomden dat... we in de wolken waren! | 2000 | Wilma van den Bosch | Centrefold or poster | 2 | Holland | 23 |
| We droomden dat... we piraten waren! | 2000 | Wilma van den Bosch | Centrefold or poster | 2 | Holland | 22 |
| We droomden dat... we robots hadden! | 2000 | Wilma van den Bosch | Centrefold or poster | 2 | Holland | 22 |
| We droomden dat... we op 'n onbewoond eiland waren! | 2000 | Wilma van den Bosch | Centrefold or poster | 2 | Holland | 22 |
| Canus Cavalierus | 2000 | Peter Härdfeldt, Jorge David Redo | Story | 1 | Denmark | 20 |
| 4 misteri per la Top Detectives | 2000 | Bruno Sarda, Lino Gorlero | Story | 110 | Italy | 20 |
| Ticket To Bong | 2000 | Andreas Pihl, Joaquín Cañizares Sanchez | Story | 35 | Denmark | 19 |
| Il camper | 2000 | Alessandro Perina | Story | 1 | Italy | 19 |
| Κόμιξ | 2000 | | Illustration | 1 | Non-Disney and/or non-comics | 18 |
| Untitled cover | 2000 | Michel Nadorp | Cover | 1 | Holland | 16 |
| Untitled article | 2000 | | Article | 1 | Brazil | 14 |
| Out Of Orbit | 2000 | Dave Rawson, Francisco Rodriguez Peinado | Story | 10 | Denmark | 14 |
| Valiant Vermin | 2000 | Sarah Kinney, Xavier Vives Mateu | Story | 7 | Denmark | 14 |
| Tip e Tap e il gioco dell'oca | 2000 | Massimo De Vita | Story | 30 | Italy | 14 |
| La grande delusione | 2000 | Giorgio Pezzin, Nicola Tosolini | Story | 33 | Italy | 14 |
| Topolino e la nube nera | 2000 | Giovanna Bo, Gigi Piras | Story | 32 | Italy | 13 |
| La ragione e il cuore | 2000 | Giorgio Pezzin, Ettore Gula | Story | 39 | Italy | 13 |
| Minni, Tebel e il profumo della primavera | 2000 | Giustina Porcelli, Roberto Vian | Story | 23 | Italy | 11 |
| Di nuovo insieme | 2000 | Giorgio Pezzin, Graziano Barbaro | Story | 37 | Italy | 11 |
| Untitled cover | 2000 | Francesco Artibani, Corrado Mastantuono | Cover | 1 | Italy | 11 |
| Pluto e il postino provocatore | 2000 | Luca Boschi, Donald Soffritti | Story | 13 | Italy | 10 |
| Topolino e la vendetta di Luther Blot | 2000 | Gianfranco Cordara, Giuseppe Dalla Santa | Story | 46 | Italy | 9 |
| Untitled cover | 2000 | Francesco Artibani, Corrado Mastantuono | Cover | 1 | Italy | 9 |
| Différences | 2000 | Philippe Larbier | Game or puzzle | 1 | France | 8 |
| Topolino e la foresta dei briganti | 2000 | Tito Faraci, Silvio Speca | Story | 10 | Italy | 8 |
| Pluto e il lamento del coyote | 2000 | Luca Boschi, Donald Soffritti | Story | 14 | Italy | 8 |
| Pluto in Indovina chi viene a cuccia | 2000 | Luca Boschi, Donald Soffritti | Story | 18 | Italy | 8 |
| The Finale | 2000 | Kari Korhonen, Valentin Doménech | Story | 2 | Denmark | 7 |
| 2500ste nummer | 2000 | Michel Nadorp | Cover | 1 | Holland | 7 |
| We droomden dat... we in een spookhuis woonden! | 2000 | Wilma van den Bosch | Centrefold or poster | 2 | Holland | 7 |
| We droomden dat... ons huis een speeltuin was. | 2000 | Wilma van den Bosch | Centrefold or poster | 2 | Holland | 7 |
| Untitled cover | 2000 | Fernando Güell | Cover | 1 | Denmark | 6 |
| Le doublé doublé | 2000 | Didier le Bornec, José Ramón Bernado | Story | 12 | France | 6 |
| La fiancée du fantôme | 2000 | Alain Clément, José Ramón Bernado | Story | 12 | France | 6 |
| The Hunt Is On! | 2000 | François Corteggiani, José Antonio González | Story | 1 | France | 6 |
| Telefoon | 2000 | Frank Jonker, Conrad Lazaro | Story | 2 | Holland | 6 |
| Minni e il posto delle favole | 2000 | Giorgio Di Vita, Annamaria Di Vita | Story | 28 | Italy | 6 |
| Untitled cover | 2000 | Roberta Migheli | Cover | 1 | Italy | 6 |
| Romântico Pra Cachorro! | 2000 | Lúcia de Nobrega, Dave Santana | Story | 8 | Brazil | 5 |
| Untitled cover | 2000 | Tello Art | Cover | 1 | Denmark | 5 |
| ...Pluto, detective a 4 zampe | 2000 | Caterina Mognato, Federico Bertolucci | Story | 14 | Italy | 5 |
| Topolino e le rapine di Basettoni | 2000 | Maurizio Amendola | Story | 38 | Italy | 5 |
| Pluto e la saggezza inattesa | 2000 | Alberto Savini, Lara Molinari | Story | 12 | Italy | 5 |
| Untitled cover | 2000 | | Cover | 1 | Italy | 5 |
| Uma Festa Muito Doida | 2000 | Gérson Luiz Borlotti Teixeira, Roberto O. Fukue | Story | 10 | Brazil | 4 |
| Questão de Jeito | 2000 | Lúcia de Nobrega, Napoleão Figueiredo | Story | 1 | Brazil | 4 |
| Paresse sur canapé | 2000 | Didier le Bornec, José Antonio González | Story | 10 | France | 4 |
| Le journal de Mickey nº 2500 | 2000 | Philippe Larbier | Cover | 1 | France | 4 |
| Sports divers | 2000 | Philippe Larbier | Game or puzzle | 1 | France | 4 |
| Cooler Kick | 2000 | | Game or puzzle | 2 | Germany | 4 |
| Збрка у Лоливуду | 2000 | | Game or puzzle | <1 | Germany | 4 |