| Ducktopia | 2021 | Francesco Artibani, Francesco D'Ippolito | Story | 96 | Italy | 33 |
| La macchia invisibile | 2021 | Matteo Venerus, Francesco D'Ippolito | Story | 48 | Italy | 17 |
| Calisota Summer Cup | 2021 | Marco Nucci, Stefano Intini | Story | 122 | Italy | 17 |
| Topolino e i misteri di Mister MacGuffin | 2021 | Marco Nucci, Giampaolo Soldati | Story | 28 | Italy | 15 |
| Topolino e il trionfo della macchia | 2021 | Alessandro Sisti, Blasco Pisapia | Story | 24 | Italy | 15 |
| Topolino e la micio-minaccia | 2021 | Casty, Enrico Faccini | Story | 34 | Italy | 12 |
| Pluto e l'equivoco felino | 2021 | Monica Manzoni, Luca Bonardi | Story | 6 | Italy | 11 |
| Starstruck Dog | 2021 | Sune Troelstrup, Fabrizio Petrossi | Story | 5 | Denmark | 10 |
| Watch the Birdie | 2021 | Carol McGreal, Lourdes Rueda Sala | Story | 4 | Denmark | 10 |
| Untitled cover | 2021 | Maarten Gerritsen | Cover | 1 | Holland | 8 |
| A Ilha dos Mistérios | 2021 | Lorenzo Pastrovicchio | Cover | 1 | Italy | 8 |
| Topo Principe | 2021 | Augusto Macchetto, Giada Perissinotto | Story | 50 | Italy | 6 |
| Mickey et les mille Pat | 2021 | Jean-Luc Cornette, Thierry Martin | Story | 74 | France | 5 |
| Mickey et les mille Pat | 2021 | Thierry Martin | Cover | 1 | France | 5 |
| Joyeuses fêtes | 2021 | Fabrizio Petrossi | Cover | 1 | France | 5 |
| Spookhuis in de sneeuw | 2021 | Frank Jonker, Thomas Cabellic | Story | 5 | Holland | 5 |
| Topolino e il caso della cosa nella casa | 2021 | Sisto Nigro, Andrea Malgeri | Story | 26 | Italy | 5 |
| Pippo e la tettoia indispensabile | 2021 | Rudy Salvagnini, Cristian Canfailla | Story | 16 | Italy | 4 |
| Untitled illustration | 2021 | Blasco Pisapia | Illustration | 1 | Italy | 4 |
| Untitled cover | 2021 | Francesco D'Ippolito | Cover | 1 | Italy | 4 |
| (Studi per ambientazioni e personaggi) | 2021 | Thierry Martin | Story | 1 | France | 3 |
| Projet de couverture | 2021 | Thierry Martin | Illustration | 1 | France | 3 |
| Untitled cover | 2021 | Emmanuele Baccinelli | Cover | 1 | Italy | 3 |
| Untitled cover | 2021 | Fabio Celoni | Cover | 1 | Italy | 3 |
| Artificial Intelligence! | 2021 | Alessandro Ferrari, Stefano Intini | Story | 6 | Disney Publishing Worldwide (global) | 3 |
| Untitled illustration | 2021 | Fernando Güell | Illustration | | Denmark | 2 |
| Topo Principe | 2021 | Augusto Macchetto, Giada Perissinotto | Text story | 11 | Italy | 2 |
| Pluto e il trionfo della macchia | 2021 | Alessandro Sisti, Blasco Pisapia | Story | 20 | Italy | 2 |
| Untitled illustration | 2021 | Giada Perissinotto | Illustration | | Italy | 2 |
| Untitled illustration | 2021 | Lorenzo Pastrovicchio | Illustration | 1 | Italy | 2 |
| Helt til grin | 2021 | | Text story | 1 | Non-Disney and/or non-comics | 2 |
| Kylpypulma | 2021 | Eppu Riihelä | Story | 1 | Non-Disney and/or non-comics | 2 |
| Luiden kimpussa | 2021 | Maija Kaivosoja | Story | 2 | Non-Disney and/or non-comics | 2 |
| Dog Days! | 2021 | | Text story | 2 | Disney Publishing Worldwide (global) | 2 |
| Untitled illustration | 2021 | Fernando Güell | Illustration | | Denmark | 1 |
| Vive les vacances | 2021 | Angel Rodriguez | Cover | 1 | France | 1 |
| Dat zoeken we op! | 2021 | Jan-Roman Pikula | Text story | 1 | Holland | 1 |
| Op bezoek bij... Knabbel & Babbel | 2021 | Lotte Roep, Jan-Roman Pikula | Illustration | 1 | Holland | 1 |
| Oom Donald's moppentrommel | 2021 | Gerben Valkema | Text story | 1 | Holland | 1 |
| Willies wereld | 2021 | | Game or puzzle | 1 | Holland | 1 |
| Waanzinnige weetjes uit het Woudlopers Handboek - Een lopend vuurtje | 2021 | Jana van de Hoek, Jan-Roman Pikula | Text story | 1 | Holland | 1 |
| Lang leve de buren! | 2021 | Pascalle Bouman, Daniel Pérez | Text story | 2 | Holland | 1 |
| Untitled cover | 2021 | Corrado Mastantuono | Cover | 1 | Italy | 1 |
| Untitled cover | 2021 | Corrado Mastantuono | Cover | 1 | Italy | 1 |
| Untitled cover | 2021 | Giorgio Cavazzano | Cover | 1 | Italy | 1 |
| Untitled illustration | 2021 | Emmanuele Baccinelli | Illustration | 1 | Italy | 1 |
| Untitled illustration | 2021 | Emmanuele Baccinelli | Illustration | | Italy | 1 |
| Untitled illustration | 2021 | Emmanuele Baccinelli | Illustration | | Italy | 1 |
| Untitled illustration | 2021 | Emmanuele Baccinelli | Illustration | | Italy | 1 |
| Untitled illustration | 2021 | Emmanuele Baccinelli | Illustration | | Italy | 1 |
| Untitled illustration | 2021 | Emmanuele Baccinelli | Illustration | | Italy | 1 |
| Untitled illustration | 2021 | Emmanuele Baccinelli | Illustration | | Italy | 1 |
| Untitled cover | 2021 | Giorgio Cavazzano | Cover | 1 | Italy | 1 |
| Untitled cover | 2021 | | Cover | 1 | Non-Disney and/or non-comics | 1 |
| Helt til grin | 2021 | | Text story | 1 | Non-Disney and/or non-comics | 1 |
| Helt til grin | 2021 | | Text story | 1 | Non-Disney and/or non-comics | 1 |
| Helt til grin | 2021 | | Text story | 2 | Non-Disney and/or non-comics | 1 |
| Den store Andeby-quiz | 2021 | | Game or puzzle | 2 | Non-Disney and/or non-comics | 1 |
| Den store Andeby-quiz | 2021 | | Game or puzzle | 2 | Non-Disney and/or non-comics | 1 |
| Disney-merchandise - del 1 | 2021 | Laila Jerming Graf | Article | 2 | Non-Disney and/or non-comics | 1 |