| Topolino e il mistero della voce spezzata | 1991 | Silvano Mezzavilla, Giorgio Cavazzano | Story | 52 | Italy | 64 |
| La guarnigione segreta | 1991 | Giorgio Pezzin, Massimo De Vita | Story | 122 | Italy | 49 |
| I misteri della giungla nera | 1991 | Bruno Sarda, Giampiero Ubezio | Story | 48 | Italy | 35 |
| Topolino e il trofeo di Topolinia | 1991 | Bruno Concina, Giorgio Cavazzano | Story | 28 | Italy | 31 |
| Topolino e un favore da nulla | 1991 | Carlo Panaro, Corrado Mastantuono | Story | 29 | Italy | 29 |
| Tom Thumb | 1991 | Donne Avenell, Ignasi Calvet Estéban | Story | 11 | Denmark | 27 |
| On the Road | 1991 | Jack Sutter, Cèsar Ferioli Pelaez | Story | 6 | Denmark | 23 |
| Santa Claus Is Missing! | 1991 | Tom Anderson, Peter Härdfeldt | Story | 12 | Denmark | 23 |
| Minni "cercasi Lucy Ann disperatamente" | 1991 | Carlo Panaro, Antoni Bancells Pujadas | Story | 27 | Italy | 22 |
| Topolino e l'indagine di Natale | 1991 | Bruno Concina, Comicup Studio | Story | 37 | Italy | 22 |
| The TV Fan | 1991 | Jack Sutter, Bernardo Serrat | Story | 7 | Denmark | 19 |
| The Evil Vampire Count Blotula | 1991 | Colette Bezio, Alex Howell | Newspaper strip | 18 | Daily strips (US) | 18 |
| Topolino e il quadro che non quadra | 1991 | Angelo Palmas, Luciano Gatto | Story | 27 | Italy | 17 |
| Topolino e le gemelle "gemelle ma non troppo" | 1991 | Alessandro Sisti, Giorgio Cavazzano | Story | 32 | Italy | 15 |
| His Last Chase | 1991 | Jack Sutter, Tello-Team | Story | 5 | Denmark | 14 |
| A Phantom Blot Bedtime Story | 1991 | Lee Nordling, Stephen DeStefano | Story | 12 | Disney Comics | 14 |
| Pašovaný tovar | 1991 | Hjemmet Oslo, Tello Art | Cover | 1 | Denmark | 13 |
| Nobody's Perfect | 1991 | Flemming Andersen, Tello-Team | Story | 1 | Denmark | 13 |
| Topolino e Little Gum fantasmi a bizzeffe | 1991 | Giulio Chierchini | Story | 103 | Italy | 13 |
| "Accès de phobie" | 1991 | Jacques Lelièvre, José Ramón Bernado | Story | 8 | France | 12 |
| Untitled cover | 1991 | | Cover | 1 | Germany | 10 |
| Buona Pasqua | 1991 | Roberto Santillo | Cover | 1 | Italy | 10 |
| The Easiest Way | 1991 | Lasse Holm, Ignasi Calvet Estéban | Story | 1 | Denmark | 9 |
| Mouseton, the Eagle has Landed and he's out for revenge | 1991 | Marv Wolfman, Mike Royer | Story | 12 | Disney Comics | 8 |
| Pluto's Quick Snack | 1991 | Michael Begovich, Joaquín Cañizares Sanchez | Story | 1 | Denmark | 7 |
| Fetch That Stick! | 1991 | Michael Begovich, Bernardo Serrat | Story | 1 | Denmark | 7 |
| Ressemblances | 1991 | Pierre le Goff | Game or puzzle | <1 | France | 7 |
| Pluto e Superpluto | 1991 | Giorgio Pezzin, Maria Luisa Uggetti | Story | 25 | Italy | 7 |
| 16 pagine di TV Magazine | 1991 | Roberto Santillo | Cover | 1 | Italy | 7 |
| Natale 1991 | 1991 | Franco Valussi | Cover | 1 | Italy | 7 |
| Väritä pisteellä merkityt kohdat | 1991 | Jordi Sanchis | Game or puzzle | 1 | Denmark | 6 |
| Untitled cover | 1991 | Tello Art | Cover | 1 | Denmark | 6 |
| Untitled cover | 1991 | photographs | Cover | 1 | France | 6 |
| La guarnigione segreta | 1991 | Massimo De Vita | Cover | 1 | Italy | 6 |
| Qua la mano telefono azzurro! | 1991 | Giorgio Cavazzano | Cover | 1 | Italy | 6 |
| When Mouseton Freezes Over! | 1991 | Marv Wolfman, Stephen DeStefano | Story | 12 | Disney Comics | 6 |
| Hail and Farewell | 1991 | Marv Wolfman, Mike Royer | Story | 12 | Disney Comics | 6 |
| It's for the Birds | 1991 | Bob Langhans, Horacio Saavedra | Story | 4 | Disney Studio (foreign market stories) | 6 |
| Untitled cover | 1991 | | Cover | 1 | Italy | 5 |
| Buon Natale | 1991 | | Cover | 1 | Italy | 5 |
| Surpresa, Mickey! | 1991 | Arthur Faria Jr., Roberto O. Fukue | Story | 6 | Brazil | 4 |
| Canine Cowboy | 1991 | Jack Sutter, Antoni Bancells Pujadas | Story | 7 | Denmark | 4 |
| Home Sweet Home!!! | 1991 | Studio Bonnet | Game or puzzle | 1 | Denmark | 4 |
| Untitled cover | 1991 | Tello Art | Cover | 1 | Denmark | 4 |
| Untitled cover | 1991 | Egmont office, Fernando Güell | Cover | 1 | Denmark | 4 |
| Méli Mélo | 1991 | Hubie Karp | Story | 1 | France | 4 |
| Untitled cover | 1991 | Rick Hoover | Cover | 2 | Disney Comics | 4 |
| Raptos Caninos | 1991 | Eli Marcos M. Leon | Story | 9 | Brazil | 3 |
| Os Teimosos | 1991 | | Illustration | <1 | Brazil | 3 |
| Untitled cover | 1991 | Tello Art | Cover | 2 | Denmark | 3 |
| Untitled centrefold or poster | 1991 | | Centrefold or poster | 2 | Germany | 3 |
| 2000ste nummer | 1991 | Daan Jippes | Cover | 1 | Holland | 3 |
| Topolino e il mistero della voce spezzata | 1991 | Giorgio Cavazzano | Cover | 1 | Italy | 3 |
| Tanti auguri | 1991 | Sergio Asteriti | Illustration | 1 | Italy | 3 |
| The Future Ain't What It Used to Be! | 1991 | Lamar Waldron, Bill Fugate | Story | 12 | Disney Comics | 3 |
| Untitled cover | 1991 | Rick Hoover | Cover | 1 | Disney Comics | 3 |
| Untitled painting | 1991 | | Painting | 1 | Posters and other promotional material | 3 |
| Untitled cover | 1991 | | Cover | 1 | United Kingdom | 3 |
| Untitled cover | 1991 | Euclides K. Miyaura | Cover | 1 | Brazil | 2 |
| Untitled cover | 1991 | Euclides K. Miyaura | Cover | 1 | Brazil | 2 |